Actively Recruiting
Direct Oral Challenges in Private Practice Setting to Delabeling Children With Beta-lactam Allergy
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-05-06
200
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
A
Assistance Publique - Hôpitaux de Paris
Lead Sponsor
U
URC-CIC Paris Descartes Necker Cochin
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to demonstrate the feasibility of direct oral challenge performed in private practice setting for children with suspected benign delayed allergy to beta-lactams. The results of this study could help establish recommendations for conducting direct oral challenge in primary care settings to delabeling children with benign delayed reactions to beta-lactams.
CONDITIONS
Official Title
Direct Oral Challenges in Private Practice Setting to Delabeling Children With Beta-lactam Allergy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Child between 0 and 17 years old
- Child has undergone a direct oral challenge in private practice for suspected delayed allergy to amoxicillin +/- clavulanate, cefpodoxime, or cefixime
- Reaction occurred more than 1 hour after starting treatment
- Reaction is mild, such as isolated urticaria or maculopapular rash
- No signs of severe skin reactions like erythroderma, bullae, vesicles, pustules, target lesions, or mucosal involvement
- Child has no facial swelling, general condition impairment, organ failure, or reaction lasting more than 7 days
- Follow-up consultation occurred within 7 to 14 days after challenge
You will not qualify if you...
- Child or parent/legal guardian objects to use of patient data in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hôpital Necker - Enfants Malades
Paris, France, 75015
Actively Recruiting
Research Team
S
Sebastien LE, MD
CONTACT
G
Gael Plastow
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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