Actively Recruiting
Discontinuation of Antithrombotic Treatment Following Patent Foramen Ovale Closure in Young Patients With Cryptogenic Stroke
Led by Josep Rodes-Cabau · Updated on 2026-03-24
100
Participants Needed
1
Research Sites
629 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To determine the safety of antithrombotic treatment discontinuation 12 months following successful transcatheter PFO closure.
CONDITIONS
Official Title
Discontinuation of Antithrombotic Treatment Following Patent Foramen Ovale Closure in Young Patients With Cryptogenic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Successful transcatheter PFO closure with any approved device
- Patients aged 60 years or younger diagnosed with a cryptogenic stroke or transient ischemic attack (TIA) who have undergone successful transcatheter PFO closure
You will not qualify if you...
- Older than 60 years
- RoPE score less than 6
- Moderate or greater residual shunt following PFO closure
- Atrial fibrillation after PFO closure
- Presence of two or more cardiovascular risk factors (smoking, hypertension, dyslipidemia)
- Diabetes mellitus
- Thrombophilia (including factor V Leiden, factor II mutation, anticardiolipin antibodies, lupus anticoagulant, anti-b2 glycoprotein-I antibodies, protein C deficiency, protein S deficiency)
- Recurrent stroke or TIA within one year after PFO closure
- Failure to provide signed informed consent
- Absolute contraindications for MRI study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
IUCPQ
Québec, Quebec, Canada, G1V 4G5
Actively Recruiting
Research Team
J
Josep Rodes-Cabau, MD
CONTACT
M
Melanie Cote, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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