Actively Recruiting
Discontinuation Study
Led by University College Cork · Updated on 2026-03-04
70
Participants Needed
1
Research Sites
252 weeks
Total Duration
On this page
Sponsors
U
University College Cork
Lead Sponsor
C
Cancer Research@UCC
Collaborating Sponsor
AI-Summary
What this Trial Is About
An interventional, non-randomised study to assess the risk of progression after discontinuation of maintenance therapy in sustained MRD negative complete remission by flow cytometry MM patients without high-risk features who have completed at least two years of maintenance therapy or who have discontinued maintenance due to side effects. The primary endpoint is to assess the rates of sustained MRD negativity by NGF in the bone marrow at 12 months after discontinuation of maintenance therapy.
CONDITIONS
Official Title
Discontinuation Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or over
- Diagnosis of multiple myeloma as first line of treatment
- Completed at least 2 years of maintenance therapy to prevent disease recurrence
- Patients who stopped maintenance earlier than 2 years due to side effects but have sustained MRD negative complete remission
- Able and willing to sign informed consent and follow study schedule
You will not qualify if you...
- Received more than one line of therapy or not completed two years of maintenance unless discontinued early with sustained MRD negative remission
- Diagnosed with other plasma cell disorders such as lymphoplasmacytic lymphoma, Waldenstrom macroglobulinemia, AL amyloidosis, or POEMS syndrome
- History of organ transplant or need for immunosuppressive therapy
- Prior allogenic hematopoietic cell transplant
- Treatment with investigational therapy not including maintenance
- Unable to sign informed consent form
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Cork University Hospital
Cork, Ireland, Ireland
Actively Recruiting
Research Team
D
Dr Vitaliy Mykytiv
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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