Actively Recruiting
Discovering New Genetic Markers in Adults and Children Who May Be At Risk for Hereditary Forms of Cancer
Led by Memorial Sloan Kettering Cancer Center · Updated on 2025-12-15
1500
Participants Needed
7
Research Sites
519 weeks
Total Duration
On this page
Sponsors
M
Memorial Sloan Kettering Cancer Center
Lead Sponsor
N
New York Genome Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is being done to attempt to identify genetic mutations or other gene-based variations in adults and children who have cancer, or are likely to develop an inherited form of cancer, and potentially reduce their risk for cancer or treat the cancer earlier.
CONDITIONS
Official Title
Discovering New Genetic Markers in Adults and Children Who May Be At Risk for Hereditary Forms of Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals who have undergone clinical and/or research genetic evaluation, found to have or not have a germline genetic variant (pathogenic, likely pathogenic, variant of uncertain/unknown significance, likely benign).
- Individuals with or without a personal history of malignant or pre-malignant lesions who demonstrate: a) clinical findings suggestive of a genetic cancer susceptibility syndrome including very early age at onset, multiple primary malignancies, or other features; and/or b) family histories suggestive of a genetic cancer susceptibility syndrome, or c) other features suggesting inherited etiology of malignancy as determined by the PI.
- Family members of the above participants. Both children (with parental consent as age appropriate) and adults are eligible to participation.
- Individuals may or may not be enrolled MSK patients; probands may be referred to (or self-referred to) the study and may be enrolled at discretion of the PI and if able to provide informed consent.
- Biospecimens derived from deceased family members may be used for research in this study if consent if provided by the executor of the estate of that individual.
You will not qualify if you...
- Patients will be excluded from this study if he/she has physical, cognitive or psychiatric conditions that interfere with ability to give meaningful informed consent.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Basking Ridge (Consent only)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Consent only)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Consent only )
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Cancer Center @ Commack (Consent Only)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (Consent only)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Consent only)
Uniondale, New York, United States, 11553
Actively Recruiting
Research Team
K
Kenneth Offit, MD, MPH
CONTACT
M
Mark Robson, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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