Actively Recruiting
Discovering New Targets for Hereditary and Sporadic Colorectal and Endometrial Cancer Risk Reduction
Led by Weill Medical College of Cornell University · Updated on 2025-09-04
1120
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
Sponsors
W
Weill Medical College of Cornell University
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are collecting and storing data, tissue samples, and personal and family histories from patients being screened for colorectal cancer and endometrial cancer during routine clinical care. The study aims to discover new genetic mechanisms and proteins related to hereditary cancer syndromes to help develop targeted therapies and prevention strategies. It also focuses on understanding how the immune system can recognize and attack tumor cells carrying mutations. Participants include those with hereditary cancer syndromes undergoing endoscopy or surgical procedures, both with and without treatment using NSAIDs, as well as average-risk individuals undergoing routine lower gastrointestinal procedures. Tissue samples such as normal mucosa, polyps, adenocarcinomas, and blood are collected during standard care procedures like endoscopy, surgery, transvaginal ultrasound, hysteroscopy, and endometrial biopsy at Weill Cornell and New York Presbyterian Hospital. Participants provide informed consent to allow collection and storage of clinical data including demographics, medical history, and outcomes. Samples are processed and stored for future research. The study will monitor novel genetic predispositions, potential therapy targets, and immune responses over a period of seven years to create a valuable hereditary colorectal and endometrial cancer registry and tissue repository.
CONDITIONS
Brief Title
Discovering New Targets for Colorectal and Endometrial Cancer Risk Reduction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of a Hereditary Cancer Syndrome by positive genetic testing and/or clinical criteria to undergo endoscopy or endometrial screening procedures
- Individuals undergoing endoscopy, transvaginal ultrasound, or hysteroscopy for average-risk screening
- Individuals diagnosed with colorectal or endometrial cancer coming for surgical treatment
- Individuals coming for diagnostic testing, clinic visits, or treatment at Weill-Cornell Medicine/NYPH
- Willingness and ability to sign informed consent
- Ability to read and understand English, Spanish, or simplified Chinese
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit
Duration - Ongoing throughout clinical procedures
Participants provide blood and tissue samples during routine clinical procedures such as endoscopy, transvaginal ultrasound, hysteroscopy, or surgery. These samples are collected for research to study genetic predisposition and cancer biology.
Samples collected during routine care visits and procedures
Duration - Up to 7 years
Participants are observed over time to facilitate discoveries related to hereditary and sporadic colorectal and endometrial cancer risk, including genetic and immune system studies.
Observation concurrent with routine clinical follow-up visits
Trial Site Locations
Total: 1 location
1
NYP/Weill Cornell Medicine
New York, New York, United States, 10065
Actively Recruiting
Research Team
S
Steven M Lipkin, MD, PhD
M
Melissa K Frey, MD, MS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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