Study of Risk Factors for Type 2 Diabetes in Overweight Youth Ages 8 to 15

What this Trial Is About

Researchers are studying the unique natural history of blood sugar control, insulin sensitivity, and beta-cell function in obese adolescents at risk for developing type 2 diabetes. This observational study aims to understand how these factors and their causes change as youth transition through puberty, providing important information that could help design future treatments and prevention strategies for youth-onset type 2 diabetes. The study will carefully examine a large group of young people at risk for type 2 diabetes using detailed biochemical, clinical, and psychosocial assessments. Participants aged 8 to 15 years who meet specific criteria related to obesity, puberty stage, and blood sugar levels will be observed over an average of 2.5 years. No treatments or medications are being tested instead, the study focuses on tracking natural changes and risk factors over time. Throughout the study, participants will undergo regular evaluations to monitor blood sugar control, beta-cell function, insulin sensitivity, and fatty acid metabolism. These measures will be collected along with clinical and psychosocial data to better understand the progression toward type 2 diabetes. The research team will review these outcomes continuously during the study period, aiming to improve knowledge about diabetes risk in youth and inform future care approaches.

DISCOVERY of Risk Factors for Type 2 Diabetes in Youth