Actively Recruiting
Disentangling the Effects of Daily Stress, Sleep, and Sex Hormones on Accelerated Vascular Aging in Midlife Women
Led by University of Delaware · Updated on 2026-05-01
30
Participants Needed
1
Research Sites
150 weeks
Total Duration
On this page
Sponsors
U
University of Delaware
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to identify the impact of estradiol (E2) on the associations between (a) responsivity to daily stress or (b) sleep variability with vascular function in midlife premenopausal women.
CONDITIONS
Official Title
Disentangling the Effects of Daily Stress, Sleep, and Sex Hormones on Accelerated Vascular Aging in Midlife Women
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female
- Age between 40 and 55 years
- Premenopausal status
You will not qualify if you...
- Pregnant, planning to become pregnant, or breastfeeding
- Peri- or post-menopausal status
- Unstable or diagnosed chronic diseases including cardiovascular, metabolic, renal, hepatic, autonomic, autoimmune, or dermatological conditions
- Current or lifetime major psychiatric illness such as major depressive disorder, bipolar disorder, schizophrenia, or eating disorders
- History of hysterectomy, polycystic ovary syndrome, endometrial hyperplasia, irregular menstrual cycles, or endometrial ablation
- Suspected obstructive sleep apnea (STOP-Bang score >3) or insomnia (Insomnia Severity Index score >15)
- Current or recent (within 8 weeks) use of medications affecting cardiovascular function or sleep health
- Changes in medication use including new or adjusted doses
- Body mass index over 35 kg/m2
- Use of tobacco or nicotine products including vaping and e-cigarettes
- Night-time or rotating shift work within the last 3 months
- Trans-meridian travel during enrollment and testing periods
- Known allergies to study drugs
- Current use of long-acting reversible contraception (e.g., IUDs, implants)
- Known latex allergy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Delaware
Newark, Delaware, United States, 19713
Actively Recruiting
Research Team
J
Jody Greaney, PhD
CONTACT
V
Virginia Nuckols, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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