Actively Recruiting
Disrupting Fear-based Memory Consolidation
Led by Emory University · Updated on 2025-10-29
66
Participants Needed
2
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This project represents a unique collaborative opportunity to pursue the essential proof-of-principle demonstration that non-invasive interference of sensory cortical memory consolidation shortly after an emotional experience can attenuate the cued fear response and potentially reduce the risk of developing post-traumatic stress disorder (PTSD). If successful, the study results would anchor a potential advance in the treatment of patients after a traumatic event and seed future animal and clinical studies of emotional sensory cortical memory consolidation to reduce the prevalence and negative sequelae of PTSD.
CONDITIONS
Official Title
Disrupting Fear-based Memory Consolidation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to provide informed consent
- Willingness to participate in study
- No history of musculoskeletal impairment or neurological disease
- Clinical diagnosis of PTSD for individuals in the PTSD group
You will not qualify if you...
- Any participant outside the age range of 18 to 65 years
- Signs of dementia (score less than 20 on the Montreal Cognitive Assessment)
- History of major head trauma, neurodegenerative disorder, or recent (less than 6 months) substance abuse
- Recent use of central nervous system active drugs that may affect brain activity or learning
- Contraindications to TMS or MRI if participating in those experiments
- Current psychoactive medication usage
- Current symptoms of psychosis or bipolar disorder
- Unable to consent, not an adult, pregnant women, or prisoners
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Emory Rehabilitation Hospital
Atlanta, Georgia, United States, 30322
Actively Recruiting
2
Emory University Hospital
Atlanta, Georgia, United States, 30322
Actively Recruiting
Research Team
M
Michael Borich, PhD
CONTACT
J
Jennifer Stevens, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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