Actively Recruiting
Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
Led by Washington University School of Medicine · Updated on 2026-03-12
50
Participants Needed
1
Research Sites
229 weeks
Total Duration
On this page
Sponsors
W
Washington University School of Medicine
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.
CONDITIONS
Official Title
Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Referral for initial ECT index course for Treatment-Resistant Depression (TRD), including unipolar major depressive disorder or bipolar depression
- History of failure to respond or achieve remission after at least two antidepressant medications at sufficient dose and duration
You will not qualify if you...
- Diagnosis of schizophrenia or schizoaffective disorders
- Inability to tolerate the DREEM device for sleep recordings
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Washington University School of Medicine/Barnes-Jewish Hospital
St Louis, Missouri, United States, 63110
Actively Recruiting
Research Team
R
Robby Greenspan
CONTACT
M
MohammadMehdi Kafashan
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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