Study of Immune Responses in Adults Aged 18 to 60 With Influenza or COVID-19 Infection, Including Vaccination Status and Optional Bronchoscopy

What this Trial Is About

This research aims to understand the immune response in adults who are symptomatic with confirmed influenza or COVID-19 infections. It compares people who have and have not been vaccinated against these viruses within the past year, focusing on how their immune systems react to acute respiratory infections caused by these viruses. Participants include those with active symptoms and a control group who have been vaccinated but not infected recently. Participants are grouped based on their infection status and vaccination history, including uninfected vaccinated individuals and those infected with either influenza or SARS-CoV-2, with or without recent vaccination. All participants attend five visits for data collection and sample testing, including blood, saliva, and nasal swabs, at enrollment, day 7, between days 10 to 28, day 90, and day 180. An optional bronchoscopy procedure, including bronchoalveolar lavage and endobronchial biopsy, may be performed twice in some participants, along with chest X-rays, though this is not required. During the study, participants undergo immune system evaluations through various sample collections and tests at specified time points to measure antibody levels and T cell responses in different body areas. Researchers monitor immune response changes from the time of infection through six months after enrollment. Safety screenings occur for those opting for bronchoscopy to ensure suitability. The entire study participation lasts approximately six months with multiple visits and assessments focused on understanding immune dynamics in respiratory viral infections.

Dissecting Human Immune Responses to Infection With Influenza or SARS-CoV-2