Actively Recruiting
Distribution of the Homologous Recombination-related (HRR) Genesmutationsand HRD in Breast Cancer
Led by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Updated on 2025-10-03
255
Participants Needed
1
Research Sites
251 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a cross-sectional and an observational study, investigator-initiated study in HER2-low breast cancer patients. Approximately 255 subjects with HRD (homologous recombination deficiency) assessment will be enrolled in this study to examine the distribution and features of HRD/HRR (homologous recombination repair). In this study, investigators plan to clarify the frequency of HRR/HRD in Chinese patients with HER2-low breast cancer. In addition, it is planned to investigate any association between invasive disease-free survival (iDFS)/overall survival (OS) and HRD/HRR in HER2-low breast cancer patients.
CONDITIONS
Official Title
Distribution of the Homologous Recombination-related (HRR) Genesmutationsand HRD in Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients aged 18 to 70 years with pathologically confirmed HER2-low breast cancer (IHC 2+/ISH- or IHC 1+ per ASCO/CAP guidelines)
- ECOG performance status of 0 or 1
- Treatment-naïve operable primary breast cancer with completed homologous recombination deficiency (HRD) assessment
- Absence of distant metastasis
- Availability of adequate tumor tissue and blood samples for biomarker analysis
You will not qualify if you...
- Recurrent or inoperable locally advanced breast cancer
- Bilateral breast cancer
- History of other malignant tumors within the past 5 years
- Incomplete clinical or pathological data
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Guangzhou, Guangdong, China, 510120
Actively Recruiting
Research Team
G
Gong Chang, doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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