Actively Recruiting
Comparison Between the Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures: A Randomized Controlled Trial
Led by Cairo University · Updated on 2026-01-21
106
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the diuretic effects of Aminophylline compared to Furosemide in adults undergoing cardiac surgery. Acute kidney injury (AKI) is a common serious complication after cardiac surgery, and while loop diuretics like furosemide may reduce kidney function post-surgery, Aminophylline might help reduce AKI frequency in high-risk patients. This trial aims to compare these two drugs in this context. Participants will be randomly assigned to receive either Aminophylline or Furosemide during their cardiac surgical procedures. The study focuses on adult patients having elective cardiac surgeries involving cardiopulmonary bypass, including coronary artery bypass, valve repairs, septal defect repairs, congenital heart defect surgeries, transplantation, or thoracic aneurysm surgery. During the study, researchers will measure urine output two hours after cardiopulmonary bypass as the primary outcome. Additional assessments include urine output, urea, creatinine, lactate levels, estimated glomerular filtration rate, and fluid balance up to 48 hours after surgery. The trial will monitor these outcomes to understand the diuretic effects and kidney function, with participation lasting through the immediate postoperative period.
CONDITIONS
Brief Title
Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age from 18 to 65 years
- Both sexes
- Adults scheduled for elective cardiac surgical procedures using cardiopulmonary bypass, including coronary artery bypass, valve repair or replacement, septal defect repair, congenital heart defect surgery, transplantation, or thoracic aneurysm surgery
- Body mass index (BMI) between 20 and 40 kg/m2
You will not qualify if you...
- Allergy or sensitivity to Aminophylline or Furosemide
- Stage 5 chronic kidney disease with glomerular filtration rate under 15 mL/min
- Chronic kidney disease with GFR less than 60 mL/min and albumin over 30 mg/g creatinine for more than 3 months
- Receiving dialysis before surgery
- Previous solid-organ transplantation
- Emergency cardiac surgeries
- Patient refusal to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of the cardiac surgical procedure and immediate postoperative period
Participants receive either Aminophylline or Furosemide during their cardiac surgery to assess the diuretic effect.
1 treatment visit during surgery
Duration - 48 hours after cardiopulmonary bypass
Participants are monitored for urine output and kidney function up to 48 hours after cardiopulmonary bypass.
Approximately 2 post-operative visits
Trial Site Locations
Total: 1 location
1
Cairo University
Cairo, Egypt, 12613
Actively Recruiting
Research Team
A
Ahmed M Hassan, MSc
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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