Comparing Aminophylline and Furosemide for Diuretic Effects in Adults Undergoing Heart Surgery

What this Trial Is About

Researchers are evaluating the diuretic effects of Aminophylline compared to Furosemide in adults undergoing cardiac surgery. Acute kidney injury AKI is a common serious complication after cardiac surgery, and while loop diuretics like furosemide may reduce kidney function post-surgery, Aminophylline might help reduce AKI frequency in high-risk patients. This trial aims to compare these two drugs in this context. Participants will be randomly assigned to receive either Aminophylline or Furosemide during their cardiac surgical procedures. The study focuses on adult patients having elective cardiac surgeries involving cardiopulmonary bypass, including coronary artery bypass, valve repairs, septal defect repairs, congenital heart defect surgeries, transplantation, or thoracic aneurysm surgery. During the study, researchers will measure urine output two hours after cardiopulmonary bypass as the primary outcome. Additional assessments include urine output, urea, creatinine, lactate levels, estimated glomerular filtration rate, and fluid balance up to 48 hours after surgery. The trial will monitor these outcomes to understand the diuretic effects and kidney function, with participation lasting through the immediate postoperative period.

Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures