Testing Diuretics to Predict Chronic Kidney Disease Progression Comparing Kidney Function in Patients and Healthy Volunteers

What this Trial Is About

Researchers are investigating how diuretic testing can predict the progression of chronic kidney disease CKD. The study focuses on whether poorer results from this test indicate faster worsening of CKD. It also compares the test results between patients with CKD and healthy individuals to understand differences in kidney function. Participants are randomly assigned to one of two groups one group receives diuretics hydrochlorothiazide and bumetanide to stimulate kidney tubular function, while the other group does not receive diuretics. Blood and urine samples are collected after administration to assess kidney response. This interventional study involves a test day where diuretics are given and monitoring occurs. During the study, participants will undergo diuretic testing with blood and urine collections to evaluate kidney function. Researchers will monitor the progression of CKD over three years as the primary outcome. Safety and adherence will be observed, and participants health will be assessed throughout the study period. The total involvement includes initial testing and long-term follow-up to measure disease progression.

Diuretic Testing in Chronic Kidney Disease