Actively Recruiting
Diuretic Tuner Clinical Decision Support
Led by University of Texas Southwestern Medical Center · Updated on 2025-09-16
30
Participants Needed
1
Research Sites
140 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This purpose of this study is to determine the effectiveness of a mobile phone application in helping to control body swelling in patients with kidney problems. The application will help in the day to day adjustments in diuretic medication dosing. Participants in this study will have an application loaded on to their mobile phone by the study team and be taught how to use it over a 2 hour visit. Participants will need to check their blood pressure and weight daily and enter this information into the mobile phone application every day. Participants will need to follow daily instructions in their medication dosing provided by the application. There will be periodic blood testing. This will happen at 2 weeks, 90 days, and up to 4 other times if necessary. At the end of the study there is a 2 hour study visit during which participants will answer a survey. The total length of the study is 90 days.
CONDITIONS
Official Title
Diuretic Tuner Clinical Decision Support
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presence of nephrotic range proteinuria (> 3 g/day) or stage 4 or 5 chronic kidney disease (eGFR < 30 mL/min/1.73 m2)
- Clinical signs of hypervolemia such as lower extremity edema, ascites, or pleural effusions
- Estimated dry weight defined as edema-free weight without orthostatic hypotension, at least 5 lbs less than enrollment body weight
You will not qualify if you...
- Body weight less than 100 lbs or greater than 300 lbs
- Autonomic insufficiency causing orthostatic hypotension at screening
- Low potassium levels at enrollment (serum potassium < 3.5 mmol/L)
- Moderate to severe low sodium at enrollment (serum sodium < 130 mmol/L)
- Serum creatinine greater than 6 mg/dL or more than 1.5 times baseline
- Unable or unwilling to measure home blood pressures and weights
- No working phone number or smartphone device
- Expected to require dialysis within less than 3 months
- Expected lifespan less than 6 months
- Medical conditions interfering with app use (dementia, illiteracy, blindness)
- Pregnant patients
- Prisoners
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Texas Southwestern
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
K
Kamalanathan K Sambandam, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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