Mobile App Support for Adjusting Diuretic Medication in Adults with Kidney Disease and Fluid Overload

What this Trial Is About

Researchers are evaluating a mobile phone application called the Diuretic Tuner to help control body swelling in patients with kidney problems, specifically those with hypervolemia due to nephrotic syndrome or advanced chronic kidney disease stage 4 or 5. This nonrandomized, uncontrolled trial aims to test the feasibility and safety of using this app to assist patients in adjusting their diuretic medication daily based on their weight and blood pressure. The study is sponsored by the University of Texas Southwestern Medical Center and focuses on achieving and maintaining an estimated dry weight without excess fluid. Participants will have the Diuretic Tuner application installed on their smartphones during a 2-hour visit where they will also learn how to use it. The app integrates each patients estimated dry weight and starting diuretic dose, both defined by their healthcare provider, with daily weight and blood pressure measurements entered by the patient. The app provides daily personalized dosing instructions and creates a diary tracking weights, blood pressure, fluid intake, and medication adherence. Blood tests will be done at 2 weeks, 90 days, and up to four additional times if needed. The total study duration is 90 days, ending with a final 2-hour visit to complete a survey about the apps usability. During the study, participants will monitor their blood pressure and weight every day and enter this data into the app. Researchers will assess how quickly and stably participants reach their target dry weight over 90 days. They will also monitor safety outcomes including hospitalization rates, low potassium levels, and kidney function changes. Usability of the Diuretic Tuner app will be evaluated through participant surveys. The study involves close monitoring with periodic lab tests and a final visit for feedback, helping researchers understand the apps potential to support self-management of fluid control in kidney disease.

Diuretic Tuner Clinical Decision Support