Actively Recruiting

Phase Not Applicable
Age: 18Years - 60Years
All Genders
Healthy Volunteers
ID06893029

Visually Induced Dizziness in Concussed and Non-Concussed Dizzy Patients: Identifying the Pathophysiology of Postural Control Upon Optokinetic Stimuli

Led by Dominik Straumann · Updated on 2025-09-19

240

Participants Needed

2

Research Sites

30 weeks

Total Duration

On this page

Sponsors

D

Dominik Straumann

Lead Sponsor

U

University Hospital, Zürich

Collaborating Sponsor

AI-Summary

What this Trial Is About

This research project studies how balance is affected by special visual stimulation called optokinetic stimulation, which can cause dizziness known as visually induced dizziness (VID). The study focuses on patients with ongoing symptoms after a concussion and those with non-traumatic dizziness, comparing them to healthy participants to better understand the balance and symptom responses. The aim is to improve objective diagnosis of VID and support better treatment and management for affected patients. Participants undergo optokinetic stimulation using either a physical rotating disc or virtual reality goggles that display bright moving dots in specific patterns and directions. Healthy subjects experience a cross-over design, receiving both physical and virtual stimulations in varied sequences, while patients are examined with either physical or virtual stimulation to avoid excessive symptoms. Each stimulation trial lasts about 30 seconds in a controlled dark environment. During the study, researchers record participants' balance responses and document symptoms like dizziness, headache, and nausea at multiple time points during and after stimulation. The main outcome measures include the sensitivity of postural responses to visual stimuli, different postural characteristics, and the severity of visually induced dizziness. The study runs from May 2025 until October 2027, involving randomized participant allocation and single masking to support reliable assessment.

CONDITIONS

Brief Title

Dizziness Due to Visual Stimuli in Patients With Concussion and Other Causes of Dizziness: Examination of Balance Behaviour

Who Can Participate

Age: 18Years - 60Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 18 and 60 years
  • Binocular vision
  • Recent concussion or mild traumatic brain injury within 4 weeks to 18 months post-injury for concussed patients
  • Diagnosis related to dizziness or visually induced dizziness within 4 weeks to 18 months for non-concussed dizzy patients, including vestibular migraine
  • Signed informed consent form or general consent for retrospective inclusion if informed consent form cannot be obtained
Not Eligible

You will not qualify if you...

  • Body mass index greater than 30
  • Acute vestibular syndrome lasting at least 24 hours
  • Severe visual impairment that cannot be corrected
  • Balance issues not related to dizziness, including neurological conditions like migraine, orthopaedic conditions like lower extremity injury, infectious diseases, or other medical causes
  • Dizziness caused by prescribed drugs, substance abuse, or mental disorders
  • Cognitive impairments that affect understanding of tasks
  • History of traumatic brain injury in the last 12 months
  • History of severe traumatic brain injury with lasting impairments
  • Other confounding issues such as psychiatric diseases
  • Frequent episodes of rotatory vertigo

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Single day

Participants undergo objective balance assessments using physical and/or virtual optokinetic stimulation to evaluate postural responses under different visual stimuli.

1 to 2 visits depending on assigned intervention sequence

Trial Site Locations

Total: 2 locations

1

BrainCare Medical Group

Zurich, Canton of Zurich, Switzerland, 8002

Actively Recruiting

2

University Hospital Zurich, Department of Neurology

Zurich, Canton of Zurich, Switzerland, 8006

Actively Recruiting

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Research Team

D

Dominik Straumann, Prof. Dr. med.

S

Samuel Meyer, MSc

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

DIAGNOSTIC

Number of Arms

4

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Published Research Related To This Trial

Visual contribution to postural stability: Interaction between target fixation or tracking and static or dynamic large-field stimulus.

J Laurens, L Awai, C J Bockisch...

https://pubmed.ncbi.nlm.nih.gov/19775892

Sport-related Concussion Clinical Profiles: Clinical Characteristics, Targeted Treatments, and Preliminary Evidence.

Anthony P Kontos, Alicia Sufrinko, Natalie Sandel...

https://pubmed.ncbi.nlm.nih.gov/30855306

The Effect of Optokinetic Stimulation on Perceptual and Postural Symptoms in Visual Vestibular Mismatch Patients.

Angelique Van Ombergen, Astrid J Lubeck, Vincent Van Rompaey...

https://pubmed.ncbi.nlm.nih.gov/27128970

Consensus statement on concussion in sport: the 6th International Conference on Concussion in Sport-Amsterdam, October 2022.

Jon S Patricios, Kathryn J Schneider, Jiri Dvorak...

https://pubmed.ncbi.nlm.nih.gov/37316210

Comparison of Clinical Balance and Visual Dependence Tests in Patients With Chronic Dizziness With and Without Persistent Postural-Perceptual Dizziness: A Cross-Sectional Study.

Charlotte De Vestel, Willem De Hertogh, Vincent Van Rompaey...

https://pubmed.ncbi.nlm.nih.gov/35685740