Actively Recruiting
DOAC in Patients with Child a or B Liver Cirrhosis
Led by Centre Hospitalier Universitaire Vaudois · Updated on 2025-02-13
40
Participants Needed
1
Research Sites
123 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate pharmacokinetics and pharmacodynamics of direct oral anticoagulant drugs (DOAC), specifically apixaban and edoxaban, in patients with Child A or B liver cirrhosis (LC). The primary objective of this study is to verify the ability of apixaban and edoxaban to decrease in vivo thrombin generation in LC patients. Participants will be randomly assigned to either apixaban (Eliquis®) or edoxaban (Lixiana®) at a therapeutic dosage for 7 consecutive days. The results of this investigation will contribute to designing a prospective multicentre interventional study to investigate the efficacy of DOAC to improve clinical outcomes in patients with LC
CONDITIONS
Official Title
DOAC in Patients with Child a or B Liver Cirrhosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Patient with previously diagnosed liver cirrhosis Child A or B
- Written informed consent
You will not qualify if you...
- Pregnancy
- Oesophageal varices with grade superior to 1 or with red signs
- Active ulcer disease of the gastrointestinal tract
- History of haemorrhagic stroke
- Severe uncontrolled hypertension
- Recent brain, spinal or ophthalmic surgery
- Kidney function inadequate for DOAC treatment
- Concomitant treatment with anti-platelet drugs
- Concomitant treatment with anticoagulant drugs (VKA, LMWH, DOAC)
- Any contraindications for DOAC administration
- Inability to give informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Centre Hospitalier Universitaire Vaudois (CHUV)
Lausanne, Canton of Vaud, Switzerland, 1011
Actively Recruiting
Research Team
L
Lorenzo Alberio, Prof Dr. med
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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