Actively Recruiting
Docetaxel, Oxaliplatin and 5-FU for Gastric Cancer With Inoperable Malignant Bowel Obstruction
Led by Sixth Affiliated Hospital, Sun Yat-sen University · Updated on 2024-03-18
79
Participants Needed
1
Research Sites
285 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multi-center, non-randomized, 3-cohort, phase II trial, evaluating a triplet combination of docetaxel, oxaliplatin and fluorouracil for gastric cancer with peritoneal carcinomatosis and inoperable malignant bowel obstruction.
CONDITIONS
Official Title
Docetaxel, Oxaliplatin and 5-FU for Gastric Cancer With Inoperable Malignant Bowel Obstruction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 to 75 years
- ECOG performance status 0 to 3
- Pathological diagnosis of gastric or gastroesophageal junction adenocarcinoma
- Peritoneal carcinomatosis confirmed by imaging or pathology
- Malignant bowel obstruction below the Treitz ligament by clinical or radiological findings
- Inoperable malignant bowel obstruction confirmed by two independent surgeons
- Hemoglobin 60 g/L or higher, white blood cell count 4x10^9/L or higher, absolute neutrophil count 2x10^9/L or higher, platelet count 100x10^9/L or higher
- Serum creatinine at or below the upper normal limit
- Total bilirubin, AST, ALT, and alkaline phosphatase all at or below 1.5 times the upper normal limit
- Provided written informed consent
You will not qualify if you...
- Prior treatment with a regimen containing all study drugs (docetaxel, oxaliplatin, fluorouracil)
- Allergy to any of the study drugs
- HER-2 amplification or overexpression, mismatch repair protein deficiency, or high microsatellite instability
- Strangulated intestinal obstruction
- Active gastrointestinal bleeding
- Uncontrolled active infection
- Severe heart disease with serious ECG abnormalities or conditions affecting treatment
- Severe lung diseases such as interstitial pneumonia, pulmonary fibrosis, or severe emphysema
- Mental disorders affecting treatment or central nervous system diseases
- Presence of brain or meningeal metastases
- HIV infection or untreated active hepatitis
- Requirement for bowel surgery or stenting due to obstruction
- Pregnant or breastfeeding women
- Other conditions deemed unsuitable for study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Sixth Affiliated hosipital, Sun Yat-Sen University
Guangzhou, Guangdong, China, 510000
Actively Recruiting
Research Team
J
Jian Xiao, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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