Adaptive Transcutaneous Magnetic Stimulation to Treat Posttraumatic Peripheral Neuropathic Pain in Veterans and Military Personnel

What this Trial Is About

This research aims to evaluate whether adaptive transcutaneous magnetic stimulation AtMS can reduce pain caused by post-traumatic peripheral neuropathic pain PTP-NP in Veterans and active military personnel. The study also examines the safety of AtMS and compares its effects on pain relief, function improvement, and mood enhancement against fixed tMS FtMS and sham tMS treatments. Researchers want to determine if AtMS is the most effective form of tMS for treating PTP-NP. Participants will be randomly assigned to one of three groups AtMS, FtMS, or Sham-tMS. Treatments consist of 8 sessions over 16 weeks, involving a patient machine interface PMI to set treatment intensity. The study includes a pre-treatment assessment phase, an induction treatment phase with five weekday sessions, and a post-treatment assessment and maintenance phase with scheduled follow-up visits. Sham-tMS mimics the active treatment without therapeutic effect, while AtMS and FtMS use active coils with different intensity settings. Participants will visit the clinic 12 times over about 5 months for assessments, treatments, and check-ups. They will keep a daily diary tracking pain intensity, sleep interference, and pain medication usage. Researchers will measure neuropathic pain rating, mood, sleep interference, and different aspects of functionality from the start to end of treatment. Safety monitoring and evaluation of medication use and sensory thresholds are also included in the study.

DoD AtMS for Posttraumatic Peripheral Neuropathic Pain