Actively Recruiting
DOLCE: Determining the Impact of Optellum's Lung Cancer Prediction Solution
Led by Nottingham University Hospitals NHS Trust · Updated on 2025-04-08
2000
Participants Needed
10
Research Sites
123 weeks
Total Duration
On this page
Sponsors
N
Nottingham University Hospitals NHS Trust
Lead Sponsor
O
Optellum Ltd.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is a multi-centre prospective observational cohort study recruiting patients with 5-30mm solid and part-solid pulmonary nodules that have been detected on CT chest scans performed as part of routine practice. The aim is to determine whether physician decision making with the AI-based LCP tool, generates clinical and health-economic benefits over the current standard of care of these patients.
CONDITIONS
Official Title
DOLCE: Determining the Impact of Optellum's Lung Cancer Prediction Solution
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 35 years or older
- Have a baseline CT scan showing at least one solid or part-solid pulmonary nodule with a solid component of 80% or more
- The nodule is not fully calcified
- Nodule size between 5 and 30 mm inclusive in maximum axial diameter measured manually
- Baseline CT includes at least one series that meets VNC instructions for use
- CT scan includes at least one full-inspiration breath-hold scan without high contrast media and no significant quality issues (e.g., motion artefacts)
You will not qualify if you...
- Diagnosed with cancer in the last 5 years
- Have thoracic implants that affect the appearance of the nodule on imaging
- Have more than five reported pulmonary nodules of any size or type, excluding fully calcified nodules
- Have additional nodules that are under follow-up according to standard pulmonary nodule care
- Have pure ground glass opacity nodules 5 mm or larger in maximum axial diameter
- Have nodules larger than 30 mm in maximum axial diameter
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 10 locations
1
Betsi Cadwaladr University Health Board
Bangor, United Kingdom
Actively Recruiting
2
Frimley Health NHS Foundation Trust (Wexham Park Hospital)
Frimley, United Kingdom
Actively Recruiting
3
Leeds Teaching Hospitals NHS Trust
Leeds, United Kingdom
Actively Recruiting
4
King's College Hospital NHS Foundation Trust
London, United Kingdom
Actively Recruiting
5
Royal Free Hospital
London, United Kingdom
Actively Recruiting
6
St. George's University Hospitals NHS Foundation Trust
London, United Kingdom
Actively Recruiting
7
The Royal Marsden NHS Foundation Trust
London, United Kingdom
Actively Recruiting
8
University College London Hospitals NHS Foundation Trust
London, United Kingdom
Actively Recruiting
9
Nottingham University Hospitals NHS Trust
Nottingham, United Kingdom
Actively Recruiting
10
Oxford University Hospitals NHS Foundation Trust
Oxford, United Kingdom
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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