Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT06143332

Domain-specific Aerobic Exercise Training in Coronary Artery Disease

Led by Western University, Canada · Updated on 2025-04-11

105

Participants Needed

1

Research Sites

121 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Exercise training in cardiac rehabilitation (rehab) is a key part of managing a patient with heart disease. It has been shown that cardiac patients who increase their aerobic ("cardio") fitness by exercise training live longer, have better quality of life, and stay out of hospitals more than patients who do not improve their aerobic fitness. The more a patient improves their aerobic fitness the greater the benefit. But it has been shown that more than half of patients do not improve their aerobic fitness even after participating in cardiac rehab. This may be related to how hard patients are asked to train (their training "intensity"). The way intensity is chosen in current programs is commonly based on a "one-size fits all" method that may not consider that different patients have different abilities. There are more personalized methods to determine training intensity that exist, but these have never been used in cardiac rehab. One method divides intensity into three zones (zone 1 = moderate intensity; zone 2 = heavy intensity; zone 3 = very high intensity) that are based on when an individuals' biological responses to exercise change. The purpose of this study is to see if this approach gives better results in terms of changes in aerobic fitness and if training in the different zones makes a difference. Three groups of patients will be asked to train for 3 months in one of the three intensity zones. Aerobic fitness before and after exercise training will be compared to see which intensity zone results in the largest change.

CONDITIONS

Official Title

Domain-specific Aerobic Exercise Training in Coronary Artery Disease

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients with coronary artery disease without left ventricular dysfunction (LVEF 50% or higher)
  • Discharged from hospital after acute coronary syndrome (ST-elevation or non-ST-elevation myocardial infarction) treated with PCI or CABG
  • Referred to St. Joseph's Cardiac Rehabilitation Program
  • Completed cardiopulmonary exercise testing at St. Joseph's and cleared to exercise without contraindications to maximal exercise
  • No respiratory or musculoskeletal issues preventing cycling exercise
Not Eligible

You will not qualify if you...

  • Diagnosed heart failure
  • Severe aortic stenosis
  • Congenital coronary abnormality
  • 2nd or 3rd degree atrioventricular block
  • Major arrhythmias such as atrial fibrillation (including paroxysmal)
  • Scheduled for PCI or CABG surgery within 2 months after hospital discharge
  • Using insulin for diabetes
  • Diagnosed respiratory disease
  • Musculoskeletal problems prohibiting cycling exercise
  • Unable to provide informed consent

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

The University of Western Ontario

London, Ontario, Canada, N6A3K7

Actively Recruiting

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Research Team

D

Daniel A Keir, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

3

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