Actively Recruiting
Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)
Led by VA Connecticut Healthcare System · Updated on 2025-09-19
160
Participants Needed
1
Research Sites
251 weeks
Total Duration
On this page
Sponsors
V
VA Connecticut Healthcare System
Lead Sponsor
Y
Yale University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of the project is to evaluate whether donepezil + cognitive remediation therapy is superior to placebo in reducing heavy drinking in patients with alcohol use disorder in a double-blind, placebo-controlled trial.
CONDITIONS
Official Title
Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females 18-80 years of age
- Fluency in English and a 6th grade or higher reading level
- Meets DSM-5 criteria for current alcohol use disorder primary diagnosis
- Last alcohol use and at least one heavy drinking day within the past 30 days
- Willingness to attend follow-up assessments at 13 weeks
- Willingness to submit to Urine Toxicology screenings
You will not qualify if you...
- Lifetime diagnosis of a psychotic disorder not caused by drug use
- Current treatment with opioids or benzodiazepines
- Involvement in a legal case that may lead to incarceration during the study
- Residential plans interfering with participation
- Medical illness significantly affecting cognition (e.g., Parkinson's, Alzheimer's, Huntington's chorea, moderate or greater TBI)
- Uncorrected sensory impairment seriously interfering with cognitive training
- Pre-morbid IQ estimate below 70
- Unstable housing or lack of commitment to remaining in geographic area for follow-up
- Unwillingness to provide contact information for follow-up
- Allergy to donepezil
- Unstable cardiovascular or other unstable medical conditions
- Imminent suicidal or homicidal risk
- Pregnant or nursing women, positive pregnancy test, or inadequate birth control in women of childbearing potential
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
VA Connecticut Healthcare System
West Haven, Connecticut, United States, 06516
Actively Recruiting
Research Team
G
Gihyun Yoon, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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