Actively Recruiting
Don't be Late! Postponing Cognitive Decline and Preventing Early Unemployment in People With Multiple Sclerosis
Led by Amsterdam UMC, location VUmc · Updated on 2025-04-03
270
Participants Needed
1
Research Sites
176 weeks
Total Duration
On this page
Sponsors
A
Amsterdam UMC, location VUmc
Lead Sponsor
U
Universiteit Leiden
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this randomized controlled trial is to compare the effectiveness of two innovative interventions aimed at preventing cognitive decline and work-related problems to enhanced usual care in improving quality of life in people with multiple sclerosis. Secondary objectives are: * to compare the effectiveness of the investigated interventions in improving cognitive, psychological, and work functioning, and in enhancing the brain's functional network * to examine which factors (i.e., baseline cognitive, psychological, work, and brain MRI-parameters) are predictive of the response to the investigated interventions * aim to qualitatively reflect on the process and outcome of the investigated interventions considering the perspectives of relevant stakeholders to allow for smooth and successful implementation in clinical practice Participants will follow the intervention for four months, with follow-up measurements at six months after intervention and 12 months after intervention.
CONDITIONS
Official Title
Don't be Late! Postponing Cognitive Decline and Preventing Early Unemployment in People With Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed MS diagnosis according to the McDonald 2017 criteria
- Age between 18 and 67
- No changes in disease modifying therapy in the last 3 months prior to inclusion
- No current relapse or steroid treatment in the six weeks before study visits
- Presence of mild cognitive deficits (at least one test with a Z-score between -1.0 and -1.99 on MACFIMS battery)
- Ability to participate in exercise intervention (EDSS less than 6.0)
- Meeting MRI safety criteria (no metal in body, not pregnant, no claustrophobia)
You will not qualify if you...
- Presence of neurological disorders other than MS or psychiatric disorders
- Current or past history of drug or alcohol abuse
- Unable to speak or read Dutch
- Currently on sick leave for 6 weeks or longer
- Currently pregnant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Amsterdam University Medical Centers, location VUmc
Amsterdam, Netherlands
Actively Recruiting
Research Team
J
Jip Aarts
CONTACT
S
Shalina Saddal
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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