Actively Recruiting
Doppler Flow in Tubal Ectopic Pregnancy in Diagnosis as a Predictor of Treatment Success - Conservative and MTX Treatment
Led by Meir Medical Center · Updated on 2026-04-21
60
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study "Doppler Flow in Tubal Ectopic Pregnancy as a Predictor of Treatment Success: Conservative and MTX Therapy" aims to evaluate the role of Doppler ultrasound parameters (RI, PI, and PSV) in predicting treatment success for tubal ectopic pregnancies. Ectopic pregnancies, affecting \~2% of all pregnancies (98% in fallopian tubes), pose significant risks, including rupture and maternal mortality. Diagnosis is typically achieved via transvaginal ultrasound, with Doppler imaging enhancing accuracy by detecting characteristic vascular patterns. Management options include conservative monitoring, methotrexate (MTX) therapy, or surgery, based on clinical stability, β-hCG levels, and ultrasound findings. While β-hCG levels are a known predictor of MTX treatment failure, there is no consensus on an optimal threshold. Prior research suggests increased vascularization on Doppler ultrasound may correlate with higher MTX success rates. This prospective study will involve 60 women aged 18-45 with stable, unruptured tubal ectopic pregnancies. It will assess Doppler parameters and other clinical factors as predictors of treatment success. Findings aim to address gaps in the literature and improve management strategies for tubal ectopic pregnancies.
CONDITIONS
Official Title
Doppler Flow in Tubal Ectopic Pregnancy in Diagnosis as a Predictor of Treatment Success - Conservative and MTX Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Tubal ectopic pregnancy
- Hemodynamically stable with no suspicion of rupture
- Eligible for methotrexate or conservative therapy
- Age between 18 and 45 years
You will not qualify if you...
- Intrauterine pregnancy
- Hemodynamic instability
- Suspected tubal rupture
- Other types of ectopic pregnancy such as cesarean scar, ovarian, or heterotopic pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Meir Medical Center
Kfar Saba, Israel, Israel, 4861027
Actively Recruiting
Research Team
C
Chen Manor Bar, MD
CONTACT
Y
yael Yagur, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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