Actively Recruiting
Dose-attenuated IST and Hetrombopag in Elderly (≥65 Years) Patients With Severe Aplastic Anemia
Led by Institute of Hematology & Blood Diseases Hospital, China · Updated on 2025-06-08
65
Participants Needed
1
Research Sites
230 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospetive,Single-Center, Single-Arm, Phase IIB Clinical Study.This study aims to evaluate the efficacy and safety of dose-attenuated IST combined with Hetrombopag in elderly patients (≥65 years) with VSAA/SAA.
CONDITIONS
Official Title
Dose-attenuated IST and Hetrombopag in Elderly (≥65 Years) Patients With Severe Aplastic Anemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of very severe aplastic anemia (VSAA) or severe aplastic anemia (SAA)
- Age 65 years or older
- Completion of all required screening assessments
- Ability to swallow oral medication
- Signed informed consent by patient or legal guardian if patient is incapacitated
You will not qualify if you...
- Clonal cytogenetic abnormalities, except isolated -Y or +8
- Previous treatment with anti-thymocyte globulin (ATG) or high-dose cyclophosphamide
- Prior cyclosporine or tacrolimus use longer than 12 months
- Prior thrombopoietin receptor agonist (TPO-RA) therapy longer than 3 months
- Uncontrolled malignancies or medical conditions that contraindicate ATG use
- Severe organ dysfunction, such as creatinine levels ≥177 μmol/L
- Considered unsuitable for the study by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Red Blood Cell Diseases Center
Tianjin, Tianjin Municipality, China
Actively Recruiting
Research Team
J
Jianping Li, MD
CONTACT
J
Jingyu Zhao, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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