Evaluating Manual and Electroacupuncture for Treating Functional Constipation in Adults Aged 18 to 75

What This Trial Is About

Researchers are investigating how different types of acupuncture affect people with functional constipation, a condition defined by specific criteria lasting at least six months. This study is designed as a single-center, randomized trial to understand the dose-response relationship of manual acupuncture compared to electroacupuncture. The trial also explores the biological mechanisms behind these treatments by examining changes in gut microbiota and brain activity using advanced imaging techniques. Participants are randomly assigned to one of two groups. One group receives manual acupuncture at two specific points on the body, with sessions lasting 30 minutes, three times weekly for 12 weeks. The other group receives the same acupuncture treatment combined with electrical stimulation at a set frequency and adjustable intensity for the same duration and schedule. Both treatments involve careful needle insertion techniques to induce a response called deqi. During the study, participants will be assessed regularly for bowel movement improvements, gut bacteria changes, brain function, and quality of life using various scales and imaging tests. These evaluations occur at baseline, multiple points throughout treatment, and follow-up weeks, including week 12 and 16. The main outcome measured is the percentage of participants achieving at least three complete spontaneous bowel movements per week by week 12. Safety and treatment adherence are monitored throughout the trial, which lasts approximately four months.

Dose-Effect Response in Acupuncture for Functional Constipation