Actively Recruiting
Dose Escalation for SBRT of Recurrent VT Ventricular Tachyarrhythmia - a Single Center, Phase II Clinical Trial
Led by University of Zurich · Updated on 2025-03-03
15
Participants Needed
2
Research Sites
339 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this study is to demonstrate that higher radiation doses are necessary to induce transmural scar formation which is currently assumed to be the underlying mechanism of successful long-term efficacy of VT treatment and therefore dose-escalation will lead to a significantly reduced long-term VT recurrence rate compared to the currently applied single dose of 25 Gy.
CONDITIONS
Official Title
Dose Escalation for SBRT of Recurrent VT Ventricular Tachyarrhythmia - a Single Center, Phase II Clinical Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with structural heart disease, including ischemic and non-ischemic cardiomyopathy
- Implanted ICD and/or CRT-D device
- At least one failed catheter ablation procedure to control sustained monomorphic VT using recommended techniques, or catheter ablation is not possible
- Sustained VT recurrence on optimized antiarrhythmic medication
- Age 18 years or older
- IRB-approved, written informed consent provided
You will not qualify if you...
- Patients with only premature ventricular contractions
- Patients with sustained VT or ventricular fibrillation who have acute myocardial infarction
- Patients with primary electrical disease (channelopathy)
- Patients with a reversible and treatable cause of VT (such as drug-induced or intoxication) that can be addressed otherwise
- Patients with a target area that cannot be safely and precisely defined for stereotactic radiotherapy
- Pregnancy or breastfeeding
- Inability to provide informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
University Hospital Ostrava
Ostrava, Czechia
Actively Recruiting
2
University Hospital Zurich
Zurich, Canton of Zurich, Switzerland, 8091
Actively Recruiting
Research Team
N
Nicolaus Andratschke, MD
CONTACT
M
Michael Mayinger, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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