Actively Recruiting
Dose Escalation Study With Bispecific Antibodies in Adult Patients With Lupus Nephritis
Led by Regeneron Pharmaceuticals · Updated on 2026-04-13
90
Participants Needed
11
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is researching a particular group of experimental drugs administered for a short period in the treatment of patients with Lupus Nephritis (LN). The main aim of the current study is to see how safe and tolerable the study drugs are in a long-term follow-up. This is a main study, called an umbrella study, which includes several independent smaller sub-studies. Each of these smaller main sub-studies tests different drugs at the same time, all aimed at treating LN. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)
CONDITIONS
Official Title
Dose Escalation Study With Bispecific Antibodies in Adult Patients With Lupus Nephritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Systemic Lupus Erythematosus (SLE) and Lupus Nephritis (LN) as described in the protocol
- Participant has refractory or relapsed disease as described in the protocol
- Age between 18 and 60 years
You will not qualify if you...
- History of or active severe or unstable lupus-associated neuropsychiatric disease likely requiring acute or emergent medical treatment or hospitalization
- Active overlap syndrome with mixed connective tissue disease or systemic sclerosis within 12 months prior to or during screening
- Catastrophic or severe antiphospholipid syndrome within 12 months prior to or during screening
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 11 locations
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
2
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
3
University Medical Center of the Johannes Gutenberg-University Mainz
Mainz, Germany, 55131
Actively Recruiting
4
Hallym University Sacred Heart Hospital
Anyang-si, Gyeonggi-do, South Korea, 14068
Actively Recruiting
5
Seoul National University Hospital
Seoul, South Korea, 03080
Actively Recruiting
6
Samsung Medical Center
Seoul, South Korea, 06351
Actively Recruiting
7
Hospital Regional Universitario de Malaga
Málaga, Spain, 290090
Actively Recruiting
8
Changhua Christian Hospital
Changhua, Taiwan, 500
Actively Recruiting
9
Taichung General Veterans Hospital
Taichung, Taiwan, 40705
Actively Recruiting
10
National Taiwan University Hospital
Taipei, Taiwan, 106
Actively Recruiting
11
Taipei Veterans General Hospital
Taipei, Taiwan, 112
Actively Recruiting
Research Team
C
Clinical Trials Administrator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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