Actively Recruiting
A Dose Escalation Study of NanO2 in Patients With Mild Respiratory Distress
Led by NuvOx LLC · Updated on 2026-01-28
18
Participants Needed
2
Research Sites
89 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
EXTEND is a dose escalation study of NanO2™ in patients with mild respiratory distress who are at risk for mechanical ventilation. The study will establish dosing guidelines for a Phase 2 study.
CONDITIONS
Official Title
A Dose Escalation Study of NanO2 in Patients With Mild Respiratory Distress
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Requiring supplemental oxygen but 6L or less by nasal cannula to maintain oxygen saturation above 92% or PaO2 above 60mmHg
- Admitted to a hospital with symptoms of mild respiratory distress
- Signed informed consent obtained from the subject or legally authorized representative
- Agrees to not participate in another clinical trial for mild respiratory distress treatment through Day 28
You will not qualify if you...
- Presence of extracorporeal membrane oxygenation
- Unstable hypertension
- History of severely impaired kidney function with eGFR 30 mL/min/1.73m2 or less
- Impaired liver function with decompensated cirrhosis
- Presence of pulmonary embolism at baseline
- Evidence of right ventricular heart failure
- Unstable hemodynamics requiring norepinephrine at 0.5 micrograms/kg/min or greater
- Unable to comply with study procedures
- Currently pregnant or breastfeeding
- Expected discharge or transfer from hospital within 48 hours
- Any other significant condition posing safety risk or interfering with study as judged by the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Grey Nun Community Hospital
Edmonton, Alberta, Canada, T6L 5X8
Actively Recruiting
2
Hôpital Maisonneuve Rosemont
Montreal, Quebec, Canada, H1T 2M4
Actively Recruiting
Research Team
N
NuvOx Pharma
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
3
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