Actively Recruiting
Dose-finding for Dobutamine During Transitional Circulation in Very Preterm Infants
Led by Instituto de Investigación Hospital Universitario La Paz · Updated on 2025-03-17
30
Participants Needed
3
Research Sites
257 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Single centre, dose finding trial to establish the minimum effective dose of dobutamine required to treat hemodynamic insufficiency, defined as low superior vena cava (SVC) flow, in infants below 33 weeks' gestation during transitional circulation (first 72 hours from birth).
CONDITIONS
Official Title
Dose-finding for Dobutamine During Transitional Circulation in Very Preterm Infants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Born with up to 32(+6) weeks gestation
- Presence of hemodynamic insufficiency, defined as SVC flow <51 ml/kg/min
- Signed and dated informed consent form provided by a parent or legally designated representative, which can be given before birth
You will not qualify if you...
- Neonates considered non-viable with a decision not to provide life support
- Infants with severe congenital hydrops fetalis requiring chest or peritoneal drainage before recruitment
- Infants already receiving dobutamine treatment
- Infants with congenital malformations likely to affect cardiovascular adaptation, including congenital diaphragmatic hernia, gastroschisis, or congenital heart defects
- Infants with chromosomal anomalies
- Lack of signed parental informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Hospital Universitario Quironsalud
Madrid, Spain, 28002
Actively Recruiting
2
Hospital Universitario 12 de Octubre
Madrid, Spain, 28041
Actively Recruiting
3
Hospital Universitario La Paz
Madrid, Spain, 28046
Actively Recruiting
Research Team
A
Adelina Pellicer, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
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