Actively Recruiting
A Dose-finding Study of JMKX003142 in Treatment of Renal Edema
Led by Jemincare · Updated on 2025-08-12
216
Participants Needed
2
Research Sites
81 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To Evaluate the Safety, Efficacy, and Pharmacokinetic Characteristics of JMKX003142 Administered Randomly, Open-label, Active-controlled Study in Chinese Renal Edema Patients.
CONDITIONS
Official Title
A Dose-finding Study of JMKX003142 in Treatment of Renal Edema
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who understand the study purpose and voluntarily sign informed consent
- Age 18 years or older at screening
- Diagnosed with renal edema at screening
- Estimated glomerular filtration rate (eGFR) of 15 mL/min/1.73m2 or higher at screening
You will not qualify if you...
- Receiving or expected to require renal replacement therapy soon
- Suspected hypovolemia
- Have acute thrombosis, diarrhea, or difficulty urinating
- Unable to sense thirst or difficulty with fluid intake
- Received arginine vasopressin-V2R blockers within 30 days before screening
- Abnormal liver enzymes or serum sodium above normal limits
- Abnormal D-dimer levels above twice the upper limit
- Received diuretics from 2 days before to randomization
- Blood pressure outside 90/60 mmHg to 160/100 mmHg range
- History of allergies to 3 or more substances or currently allergic
- Breastfeeding or positive pregnancy test before treatment
- Sexually active without agreeing to birth control or abstinence during and 30 days after treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Fudan University Affiliated Zhongshan Hospital
Shanghai, China, 200102
Actively Recruiting
2
Zhejiang Hangyu Pharmaceutical Co., Ltd（subsidiary of Jemincare）
Shanghai, China, 200102
Not Yet Recruiting
Research Team
L
Lin Shi
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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