Actively Recruiting
Minimum Effective Volume (MEV90) of Local Anesthetic Required for Ultrasound-Guided Interscalene Block for Supraclavicular Nerve Block: A Dose-Finding Study
Led by Hospital del Trabajador de Santiago · Updated on 2026-04-08
55
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the minimum effective volume (MEV90) of local anesthetic needed to block the supraclavicular nerves with a single ultrasound-guided interscalene brachial plexus block. These nerves provide sensation to the skin over the clavicle and shoulder and can affect pain after shoulder or clavicle surgery. The study aims to optimize pain relief while reducing risks associated with local anesthetic use. Participants receive a single-shot interscalene block using bupivacaine 0.5% with epinephrine, injected between the anterior and middle scalene muscles at the C5-C6 nerve roots under ultrasound guidance. The initial volume is 12 mL, adjusted in 2 mL steps up to a maximum of 30 mL according to a dose-finding design. Experienced anesthesiologists perform all blocks following safety protocols. During the study, participants are monitored closely with ECG, oxygen saturation, and blood pressure checks. Researchers assess sensory and motor block onset and effectiveness up to 30 minutes after the block, as well as pain during the procedure and any adverse events. The main outcome is identifying the minimum volume providing effective supraclavicular nerve block to guide future pain management strategies in shoulder surgery.
CONDITIONS
Brief Title
Dose-Finding Study: MEV90 for Local Anesthetic in Interscalene Block for Supraclavicular Nerves Block
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- ASA physical status I to III
- Body Mass Index (BMI) between 18 and 35 kg/m²
- Weight at least 50 kg
- Scheduled for shoulder arthroscopy requiring an interscalene brachial plexus block for analgesia
- Able to provide informed consent
You will not qualify if you...
- Unable to provide informed consent
- Coagulopathy (platelet count ≤100,000; INR ≥1.4)
- Significant pulmonary disease (restrictive or obstructive)
- Renal insufficiency (creatinine ≥1.2 mg/dL)
- Hepatic insufficiency (transaminases ≥100 U/L)
- Allergy to local anesthetics
- Pregnancy
- Pre-existing neuropathy
- Previous surgery in ipsilateral cervical or supraclavicular region
- Contralateral hemidiaphragmatic paralysis or vocal cord paralysis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single treatment event
Participants receive a single ultrasound-guided interscalene brachial plexus block with bupivacaine to achieve sensory block of the supraclavicular nerves as part of perioperative analgesia for shoulder arthroscopy.
1 visit (in-person) at the time of block procedure
Duration - Up to a few hours on the day of surgery
Participants are monitored for sensorimotor block effectiveness, pain, and any block-related adverse events during and shortly after the procedure until the end of surgery.
Continuous monitoring during and immediately after the block procedure until surgery ends
Trial Site Locations
Total: 1 location
1
Hospital del Trabajador
Providencia, Chile
Actively Recruiting
Research Team
G
Germán Aguilera, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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