Actively Recruiting
A Dose-masked Study of Intravitreal EYE103 in Participants With NVAMD or Macular Edema Following BRVO
Led by EyeBiotech Ltd. · Updated on 2025-11-19
160
Participants Needed
49
Research Sites
146 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
EYE-RES-104 is a randomized, dose-masked study of intravitreal EYE103 in participants with neovascular age-related macular degeneration (NVAMD) or macular edema following branch retinal vein occlusion (BRVO). The study will consist of 4 patient cohorts, with participants in each cohort randomized (1:1) to either a low dose of EYE103 via IVT or a high dose of EYE103 via IVT. 40 participants will be enrolled in each cohort. Enrollment timing for each cohort will be sequenced into specific arms of the study at the Sponsor's discretion. All participants in the study will receive a total of 3 injections of EYE103 into the study eye, spaced at 4 weeks apart. All participants will return at designated time points following each injection for safety and efficacy assessments. The Week 12 Visit will serve as the end of study visit for all participants.
CONDITIONS
Official Title
A Dose-masked Study of Intravitreal EYE103 in Participants With NVAMD or Macular Edema Following BRVO
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be willing and able to understand the study procedures and risks and provide written informed consent before the first study-related activity
- Be male or female aged 18 years or older
- For NVAMD participants: be 50 years or older
- Have treatment-naive subfoveal choroidal neovascularization (CNV) secondary to AMD or juxtafoveal/extrafoveal CNV with foveal involvement
- For treatment-naive NVAMD participants, diagnosis must be made within 21 days prior to Day 1 study treatment
- For incomplete responder (IR) NVAMD participants: be 50 years or older
- For IR NVAMD participants, have treatment-naive subfoveal CNV secondary to AMD or juxtafoveal/extrafoveal CNV with foveal involvement at initial screening
- For treatment-naive NVAMD participants, diagnosis must be made within 21 days prior to Screening Visit 2
- For BRVO participants: be diagnosed with BRVO in the study eye
- Have vision decrease in the study eye primarily due to BRVO
- Be treatment-naive with vision loss in the study eye and have center-involving macular edema diagnosed within 9 months of Screening
You will not qualify if you...
- Are pregnant or breastfeeding
- History of cataract surgery and/or minimally invasive glaucoma surgery in the study eye within 90 days of Screening
- Had Yttrium-Aluminum Garnet (YAG) laser capsulotomy in the study eye within 90 days of Screening
- Currently using drugs with known retinal toxicity (e.g., Hydroxychloroquine, pentosan polysulfate sodium, and amiodarone)
- Had previous thermal subfoveal laser therapy in the study eye
- Had previous photodynamic therapy with Visudyne in the study eye
- Have macular edema in the study eye caused by other conditions than BRVO (e.g., diabetic macular edema, NVAMD, Irvine-Gass syndrome)
- Have active iris or angle neovascularization or neovascular glaucoma in the study eye
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 49 locations
1
Scottsdale, Arizona
Scottsdale, Arizona, United States, 85255
Actively Recruiting
2
Scottsdale, AZ
Scottsdale, Arizona, United States, 85255
Actively Recruiting
3
Glendale, California
Glendale, California, United States, 91204
Actively Recruiting
4
Glendale, CA
Glendale, California, United States, 91204
Actively Recruiting
5
Modesto, California
Modesto, California, United States, 95356
Actively Recruiting
6
Mountain View, California
Mountain View, California, United States, 94040
Actively Recruiting
7
Sacramento, CA
Sacramento, California, United States, 95825
Actively Recruiting
8
Sactamento, California
Sacramento, California, United States, 95825
Actively Recruiting
9
Sacramento, California
Sacramento, California, United States, 95841
Actively Recruiting
10
Santa Ana, California
Santa Ana, California, United States, 92705
Actively Recruiting
11
Fort Lauderdale, Florida
Fort Lauderdale, Florida, United States, 33308
Actively Recruiting
12
Fort Lauderdale, FL
Fort Lauderdale, Florida, United States, 33308
Actively Recruiting
13
Lemont, Illinois
Lemont, Illinois, United States, 60439
Actively Recruiting
14
Lemont, IL
Lemont, Illinois, United States, 60439
Actively Recruiting
15
Hagerstown, Maryland
Hagerstown, Maryland, United States, 21740
Actively Recruiting
16
Hagerstown, MD
Hagerstown, Maryland, United States, 21740
Actively Recruiting
17
Madison, Mississippi
Madison, Mississippi, United States, 39110
Actively Recruiting
18
Madison, MS
Madison, Mississippi, United States, 39110
Actively Recruiting
19
Bloomfield, New Jersey
Bloomfield, New Jersey, United States, 07003
Actively Recruiting
20
Bloomfield, NJ
Bloomfield, New Jersey, United States, 07003
Actively Recruiting
21
Asheville, North Carolina
Asheville, North Carolina, United States, 28803
Actively Recruiting
22
Cary, North Carolina
Cary, North Carolina, United States, 27511
Actively Recruiting
23
Wake Forest, NC
Wake Forest, North Carolina, United States, 27587
Actively Recruiting
24
Wake Forest, North Carolina
Wake Forest, North Carolina, United States, 27587
Actively Recruiting
25
West Columbia, SC
West Columbia, South Carolina, United States, 29169
Actively Recruiting
26
West Columbia, South Carolina
West Columbia, South Carolina, United States, 29169
Actively Recruiting
27
Germantown, Tennessee
Germantown, Tennessee, United States, 38138
Actively Recruiting
28
Knoxville, Tennessee
Knoxville, Tennessee, United States, 37922
Actively Recruiting
29
Nashville, Tennessee
Nashville, Tennessee, United States, 37203
Actively Recruiting
30
Nashville, TN
Nashville, Tennessee, United States, 37203
Actively Recruiting
31
Abilene, Texas
Abilene, Texas, United States, 79606
Actively Recruiting
32
Amarillo, Texas
Amarillo, Texas, United States, 79106
Actively Recruiting
33
Austin, Texas
Austin, Texas, United States, 78705
Actively Recruiting
34
Austin, TX
Austin, Texas, United States, 78705
Actively Recruiting
35
Bellaire, Texas
Bellaire, Texas, United States, 77401
Actively Recruiting
36
Bellaire, TX
Bellaire, Texas, United States, 77401
Actively Recruiting
37
Burleson, Texas
Burleson, Texas, United States, 76028
Actively Recruiting
38
Dallas, Texas
Dallas, Texas, United States, 75231
Actively Recruiting
39
Dallas, TX
Dallas, Texas, United States, 75231
Actively Recruiting
40
Plano, Texas
Plano, Texas, United States, 75075
Actively Recruiting
41
Round Rock, TX
Round Rock, Texas, United States, 78681
Actively Recruiting
42
Round Rock, Texas
Round Rock, Texas, United States, 78781
Actively Recruiting
43
San Antonio, Texas
San Antonio, Texas, United States, 78240
Actively Recruiting
44
San Antonio, TX
San Antonio, Texas, United States, 78240
Actively Recruiting
45
San Marcos, Texas
San Marcos, Texas, United States, 78666
Actively Recruiting
46
The Woodlands, Texas
The Woodlands, Texas, United States, 77384
Actively Recruiting
47
The Woodlands, TX
The Woodlands, Texas, United States, 77384
Actively Recruiting
48
Willow Park, Texas
Willow Park, Texas, United States, 76087
Actively Recruiting
49
West Jordan, Utah
West Jordan, Utah, United States, 84088
Actively Recruiting
Research Team
C
Charles Miller, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
8
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