Actively Recruiting
Dose Ranging Study of ORKA-001 in Patients With Moderate-to-Severe Plaque Psoriasis
Led by Oruka Therapeutics, Inc. · Updated on 2026-03-30
160
Participants Needed
26
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multicenter, randomized, double-blinded, placebo-controlled, dose-range finding study to evaluate the efficacy and safety of ORKA-001 in adult participants with moderate-to-severe plaque psoriasis.
CONDITIONS
Official Title
Dose Ranging Study of ORKA-001 in Patients With Moderate-to-Severe Plaque Psoriasis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants 18 years of age or older
- Diagnosis of plaque psoriasis for more than 6 months
- Moderate-to-severe chronic plaque psoriasis defined by:
- Body surface area (BSA) 10% or more
- PASI score 12 or higher
- Investigator's Global Assessment (IGA) score 3 or higher on a 5-point scale
- Candidate for systemic therapy or phototherapy
- Women of childbearing potential must have a negative pregnancy test
You will not qualify if you...
- Nonplaque forms of psoriasis such as guttate, erythrodermic, pustular, or drug-induced psoriasis
- Significant history or clinical signs of metabolic, dermatological, hepatic, renal, hematologic, pulmonary, cardiovascular, gastrointestinal, neurologic, respiratory, endocrine, psychiatric disorders, or infectious diseases
- History of malignancy except non-melanoma skin cancer or cancer treated curatively at least 5 years prior without recurrence
- Known hypersensitivity to any components of ORKA-001
- Women who are breastfeeding or planning to breastfeed during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 26 locations
1
Oruka Therapeutics Investigative Site
Phoenix, Arizona, United States, 85032
Actively Recruiting
2
Oruka Therapeutics Investigative Site
North Little Rock, Arkansas, United States, 72117
Actively Recruiting
3
Oruka Therapeutics Investigative Site
Los Angeles, California, United States, 90024
Actively Recruiting
4
Oruka Therapeutics Investigative Site
Los Angeles, California, United States, 90045
Actively Recruiting
5
Oruka Therapeutics Investigative Site
San Diego, California, United States, 92123
Actively Recruiting
6
Oruka Therapeutics Investigative Site
Coral Gables, Florida, United States, 33134
Actively Recruiting
7
Oruka Therapeutics Investigative Site
Rolling Meadows, Illinois, United States, 60008
Actively Recruiting
8
Oruka Therapeutics Investigative Site
Plainfield, Indiana, United States, 46168
Actively Recruiting
9
Oruka Therapeutics Investigative Site
Rockville, Maryland, United States, 20850
Actively Recruiting
10
Oruka Therapeutics Investigative Site
Kew Gardens, New York, United States, 11415
Actively Recruiting
11
Oruka Therapeutics Investigative Site
Chapel Hill, North Carolina, United States, 27516
Actively Recruiting
12
Oruka Therapeutics Investigative Site
Cleveland, Ohio, United States, 44106
Actively Recruiting
13
Oruka Therapeutics Investigative Site
Mason, Ohio, United States, 45040
Actively Recruiting
14
Oruka Therapeutics Investigative Site
Portland, Oregon, United States, 97201
Actively Recruiting
15
Oruka Therapeutics Investigative Site
Portland, Oregon, United States, 97210
Actively Recruiting
16
Oruka Therapeutics Investigative Site
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
17
Oruka Therapeutics Investigative Site
Frisco, Texas, United States, 75033
Actively Recruiting
18
Oruka Therapeutics Investigative Site
Houston, Texas, United States, 77004
Actively Recruiting
19
Oruka Therapeutics Investigative Site
Webster, Texas, United States, 77598
Actively Recruiting
20
Oruka Therapeutics Investigative Site
Norfolk, Virginia, United States, 23502
Actively Recruiting
21
Oruka Therapeutics Investigative Site
Surrey, British Columbia, Canada, V3V 0C6
Actively Recruiting
22
Oruka Therapeutics Investigative Site
Fredericton, New Brunswick, Canada, E3B 1G9
Actively Recruiting
23
Oruka Therapeutics Investigative Site
Ajax, Ontario, Canada, L1S 7K8
Actively Recruiting
24
Oruka Therapeutics Investigative Site
Peterborough, Ontario, Canada, K9J 5K2
Actively Recruiting
25
Oruka Therapeutics Investigative Site
Montreal, Quebec, Canada, HZX 2V1
Actively Recruiting
26
Oruka Therapeutics Investigative Site
Québec, Quebec, Canada, G1V 4X7
Actively Recruiting
Research Team
O
Oruka Clinical Trials Information
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
7
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here