Actively Recruiting
Dose Ranging Study of ORKA-002 in Patients With Moderate-to-Severe Plaque Psoriasis
Led by Oruka Therapeutics, Inc. · Updated on 2026-04-22
160
Participants Needed
27
Research Sites
158 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multicenter, randomized, double-blinded, placebo-controlled, dose-range finding study to evaluate the efficacy and safety of ORKA-002 in adult participants with moderate-to-severe plaque psoriasis.
CONDITIONS
Official Title
Dose Ranging Study of ORKA-002 in Patients With Moderate-to-Severe Plaque Psoriasis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 18 to less than 80 years
- Diagnosis of plaque psoriasis for more than 6 months
- Moderate-to-severe chronic plaque psoriasis defined by Body Surface Area (BSA) of at least 10%, Psoriasis Area and Severity Index (PASI) score of at least 12, and Investigator Global Assessment (IGA) score of 3 or higher on a 5-point scale
- Candidate for systemic therapy or phototherapy
- Women of childbearing potential must have a negative pregnancy test
You will not qualify if you...
- Presence of nonplaque forms of psoriasis such as guttate, erythrodermic, pustular, or drug-induced psoriasis
- Significant history or clinical manifestations of metabolic, dermatological, hepatic, renal, hematologic, pulmonary, cardiovascular, gastrointestinal, neurologic, respiratory, endocrine, psychiatric disorders, or infectious diseases
- History of malignancy except non-melanoma skin cancer or cancer treated curatively with no recurrence for at least 5 years
- Known hypersensitivity to any components of the ORKA-002 drug product
- Women who are breastfeeding or plan to breastfeed during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 27 locations
1
Total Skin & Beauty Dermatology Center, PC DBA Total Dermatology
Birmingham, Alabama, United States, 35203
Actively Recruiting
2
First OC Dermatology Research, Inc.
Fountain Valley, California, United States, 92708
Actively Recruiting
3
TCR Medical Corporation
San Diego, California, United States, 92123
Actively Recruiting
4
Southern California Clinical Research
Santa Ana, California, United States, 92701
Actively Recruiting
5
Institute of Clinical Research and Consulting, Inc., d/b/a Clinical Science Institute
Santa Monica, California, United States, 90404
Actively Recruiting
6
Central Connecticut Dermatology Research, PLLC
Cromwell, Connecticut, United States, 06416
Actively Recruiting
7
Driven Research LLC
Coral Gables, Florida, United States, 33134
Actively Recruiting
8
Kuchnir Dermatology & Dermatologic Surgery
Milford, Massachusetts, United States, 01757
Actively Recruiting
9
Henry Ford Medical Center
Detroit, Michigan, United States, 48202
Actively Recruiting
10
Grekin Skin Institute
Warren, Michigan, United States, 48088
Actively Recruiting
11
Associated Skin Care Specialists, PA d/b/a Minnesota Clinical Study Center
New Brighton, Minnesota, United States, 55112
Actively Recruiting
12
Skin Specialists, PC dba Schlessinger MD
Omaha, Nebraska, United States, 68144
Actively Recruiting
13
Icahn School of Medicine at Mount Sinai, Department of Dermatology
New York, New York, United States, 10029
Actively Recruiting
14
WDC Cosmetic and Research, PLLC
Wilmington, North Carolina, United States, 28405
Actively Recruiting
15
Bexley Dermatology Research
Bexley, Ohio, United States, 43209
Actively Recruiting
16
Clear Choice Dermatology LLC
Warrenton, Oregon, United States, 97146
Actively Recruiting
17
Modern Research Associates, PLLC
Dallas, Texas, United States, 75231
Actively Recruiting
18
Frontier Derm Partners CRO LLC
Mill Creek, Washington, United States, 98012
Actively Recruiting
19
Alberta DermaSurgery Centre
Edmonton, Alberta, Canada, AB T6G 1C3
Actively Recruiting
20
Laser Rejuvenation Clinics Edmonton D.T. Inc.
Edmonton, Alberta, Canada, T5J 3S9
Actively Recruiting
21
Dr. Chih-ho Hong Medical Inc
Surrey, British Columbia, Canada, V3R 6A7
Actively Recruiting
22
SimcoDerm Medical and Surgical Dermatology Centre
Barrie, Ontario, Canada, L4M 7G1
Actively Recruiting
23
DermEffects
London, Ontario, Canada, N6H 5L5
Actively Recruiting
24
North Bay Dermatology Centre Inc.
North Bay, Ontario, Canada, P1B 3Z7
Actively Recruiting
25
SKiN Centre for Dermatology
Peterborough, Ontario, Canada, K9J 5K2
Actively Recruiting
26
Toronto Research Centre Inc.
Toronto, Ontario, Canada, SK S7K 2C1
Actively Recruiting
27
Alliance Clinical Trials Inc.
Waterloo, Ontario, Canada, N2J 1C4
Actively Recruiting
Research Team
O
Oruka Clinical Trials Information
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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