Actively Recruiting
Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function
Led by University of Minnesota · Updated on 2025-11-25
144
Participants Needed
1
Research Sites
74 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will assess the dose-response effects of Inspiratory Muscle Strength Training (IMST) in adults with above-normal systolic blood pressure over a 6-week period.
CONDITIONS
Official Title
Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Resting systolic blood pressure of 120 mmHg or higher measured during screening visits
- Free from serious cardiovascular or metabolic diseases based on self-report and blood tests
- No contraindications to inspiratory muscle strength training such as recent abdominal surgery, ruptured eardrum, asthma with low symptom perception, fractured ribs, or pneumothorax
- English-speaking with the ability to understand study materials and instructions
- Willing to follow pre-visit instructions including avoiding food and caffeine for at least 3 hours and avoiding vigorous exercise, alcohol, and non-prescribed medications for at least 24 hours before visits
- Non-smokers defined as not smoking cigarettes or vaping in the past year
You will not qualify if you...
- History of cardiovascular disease or ear conditions like ruptured eardrum
- Recent abdominal surgery or abdominal hernia
- Asthma with very low symptom perception, frequent severe exacerbations, or abnormally low perception of breathlessness
- Ruptured eardrum or other ear conditions
- Markedly elevated left ventricular end-diastolic volume and pressure
- Current respiratory infections such as cold, sinusitis, or respiratory tract infection (may participate after recovery)
- Pregnant or planning pregnancy during the study period
- Unable or unwilling to comply with pre-visit restrictions such as avoiding caffeine, alcohol, and exercise before visits
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
H
Hannah Westerberg
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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