Actively Recruiting
Dose-Response Impact of Geranylgeraniol (GG) Supplementation on Muscular Strength, Body Composition, Sex Steroid Hormones and CoQ10 Levels in Healthy Men and Women
Led by Lindenwood University · Updated on 2026-03-31
70
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of daily geranylgeraniol (GG) supplementation on muscle strength, body composition, and aerobic fitness in healthy, physically active adults aged 30 to 60 years. This randomized, double-blind, placebo-controlled trial aims to understand how different doses of GG influence muscle health and related physiological markers over an 8-week period. Participants will be randomly assigned to one of three groups receiving daily doses of either a placebo (olive oil), 150 mg GG, or 300 mg GG. Supplements are taken with water at a consistent time each day for 8 weeks. The study includes a screening visit and testing at baseline, week 4, and week 8 to track changes over time. During the study, participants undergo strength testing (bench press and leg press), muscular endurance assessments, aerobic capacity measurement via treadmill, and body composition analysis using advanced techniques. Blood samples will be collected to monitor metabolism-related biomarkers and safety. Participants also complete mood and quality of life questionnaires, provide dietary logs, and give fecal samples. Safety is tracked throughout, and the main outcomes focus on changes in strength and fat-free mass from start to week 8.
CONDITIONS
Brief Title
Dose-Response Impact of Geranylgeraniol (GG) Supplementation on Muscle Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 30 and 60 years old
- Body mass index values between >18.5 and <29.9 kg/m2
- Agree to maintain existing dietary patterns during the study
- Agree to refrain from alcohol, caffeine, and strenuous exercise for 24 hours before test days
- Physically active, doing at least 30 minutes of moderate exercise on at least 4 days a week
- Avoid consumption of pomegranate juice, CoQ10, vitamin B3 and its precursors, L-carnitine, MK-4
- Willing and able to comply with the study protocol
- Provided voluntary, written informed consent
You will not qualify if you...
- Body mass index <18.5 or >29.9 kg/m2
- History or current treatment for heart, cardiovascular, kidney, thyroid, liver, immune, neurological diseases, or diabetes
- Diagnosed psychiatric disorder requiring hospitalization in the past year
- History of cancer except localized skin or cervical cancer within 5 years
- Gastrointestinal abnormalities affecting swallowing or digestion
- Genetic musculoskeletal or neurologic disorders affecting muscle metabolism
- Donated blood in past 60 days
- Taking hormone therapy or hormone-boosting supplements
- Use of CoQ10 supplements in past 30 days or steroid medication in past month
- New use or dosage change of statin or hypertension medication within past 6 months
- Current smoker or quit smoking within past 6 months
- Use of drugs or supplements affecting energy expenditure or weight loss (except caffeine <300 mg/day)
- Women with hormone-related conditions like endometriosis, fibroids, or PCOS
- Pregnant, planning pregnancy, or lactating currently or within past 6 months
- Allergic or sensitive to study products
- History of alcohol or substance abuse in past 12 months
- Participation in another investigational product study within 30 days
- Participation in physical or muscle performance trials in past year
- Planning major lifestyle changes during study
- Regular competitive athletes or exercising over 360 minutes per week
- Recent exercise training or weight loss >5% in past 3 months
- Any condition that may risk participant safety or study data quality
AI-Screening
AI-Powered Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 8 weeks
Participants take a daily supplement of either placebo, 150 mg, or 300 mg of geranylgeraniol (GG) for 8 weeks while undergoing periodic assessments of muscle strength, body composition, aerobic capacity, and physiological biomarkers.
3 visits (baseline, Week 4, and Week 8)
Trial Site Locations
Total: 1 location
1
Lindenwood University Exercise and Performance Nutrition Laboratory
Saint Charles, Missouri, United States, 63301
Actively Recruiting
Research Team
A
Anthony M Hagele, MS
J
Joesi M Morey, MS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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