Actively Recruiting
Dose-Response Impact of Geranylgeraniol (GG) Supplementation on Muscle Health
Led by Lindenwood University · Updated on 2026-03-31
70
Participants Needed
1
Research Sites
73 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will evaluate the effects of daily geranylgeraniol (GG) supplementation on muscular strength, body composition, and aerobic capacity in healthy, physically active men and women. Approximately 60 participants aged 30-60 years will be enrolled in a randomized, double-blind, placebo-controlled, parallel-group trial lasting 8 weeks. Participants will be assigned to receive either placebo, 150 mg GG, or 300 mg GG daily. Outcome measures will be assessed at baseline, week 4, and week 8 and include maximal strength (1RM bench press and leg press), fat-free mass, muscular endurance, aerobic capacity (VO2peak), and circulating biomarkers related to metabolism and health.
CONDITIONS
Official Title
Dose-Response Impact of Geranylgeraniol (GG) Supplementation on Muscle Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 30 and 60 years old
- Body mass index between >18.5 and <29.9 kg/m2
- Agree to maintain current dietary habits during the study
- Agree to avoid alcohol, caffeine, and strenuous exercise for 24 hours before each test day
- Physically active with at least 30 minutes of moderate exercise on 4 or more days per week
- Avoid pomegranate juice and supplements of CoQ10, vitamin B3 and precursors, L-carnitine, MK-4
- Willing and able to follow the study protocol
- Provided voluntary, written informed consent to participate
You will not qualify if you...
- Body mass index below 18.5 or above 29.9 kg/m2
- History or current treatment of heart, cardiovascular, kidney, thyroid, liver, immune, or neurological diseases
- Diagnosed diabetes with fasting blood glucose >126 mg/dL
- Diagnosed affective or psychiatric disorder requiring hospitalization in past year
- History of cancer except localized skin or in situ cervical cancer within 5 years prior
- Gastrointestinal disorders affecting swallowing or digestion
- Genetic musculoskeletal or neurologic disorders affecting muscle metabolism
- Donated blood in past 60 days
- Treated for endocrinological disorders or using hormone supplements or replacement therapy
- CoQ10 supplement use within past 30 days or steroid medication use within one month before study
- New prescriptions or dosage changes for statins or hypertension medications within past 6 months
- Current smoker or quit smoking within past 6 months (includes all nicotine forms)
- Use of drugs or supplements affecting energy expenditure or weight loss (caffeine under 300 mg/day allowed)
- Women with hormone-related conditions such as endometriosis, fibroids, or polycystic ovary syndrome
- Pregnant, planning pregnancy, or lactating currently or within past 6 months
- Known allergy or sensitivity to study products
- Alcohol or substance abuse within 12 months prior to screening
- Use of investigational product in another study within 30 days before starting
- Participation in muscle or physical performance trials within past year
- Plans for major lifestyle changes during study
- Regular competition in sanctioned athletics or training over 360 minutes per week
- Recent exercise training or weight loss greater than 5% within 3 months
- Any condition that may compromise safety or data quality as judged by the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Lindenwood University Exercise and Performance Nutrition Laboratory
Saint Charles, Missouri, United States, 63301
Actively Recruiting
Research Team
A
Anthony M Hagele, MS
CONTACT
J
Joesi M Morey, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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