Actively Recruiting
Dose-Response to Resistance Exercise on Cardiovascular Health
Led by University of Pittsburgh · Updated on 2025-08-12
240
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
U
University of Pittsburgh
Lead Sponsor
U
University of California, Riverside
Collaborating Sponsor
AI-Summary
What this Trial Is About
A large body of evidence indicates numerous health benefits of physical activity, including prevention of cardiovascular disease (CVD), the leading cause of death in the US. This evidence has led to US Physical Activity Guidelines that recommend ≥150 min/week of moderate or ≥75 min/week of vigorous aerobic exercise (AE), plus resistance exercise (RE; such as weight lifting) on ≥2 days/week. To date, current research has mostly focused on AE, and we know a great deal about the dose-response relation between AE and health, resulting in clear and practical guidance to the public on the recommended "dose" in min/week. However, currently far less is known about the dose-response for RE: ≥2 days/week are recommended, but with no duration specified. Thus, this project aims to provide clarity on the dose relationship between RE and health. This project will significantly contribute to developing more effective CVD prevention approaches, advancing prescriptive intervention guidelines, by helping to fill the important gaps in knowledge on effective minimum dose, beneficial optimal dose, and safe maximum dose of RE for CVD prevention. Thus, advancing prescriptive intervention guidelines, and provide important insights for future science of physical activity and health.
CONDITIONS
Official Title
Dose-Response to Resistance Exercise on Cardiovascular Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Non-Smoker
- Overweight or Obese: Body Mass Index 25-43 kg/m2
- Inactive: not meeting the US resistance and aerobic exercise guidelines over the last 6 months
- Walking <7,000 steps/day at baseline
- Capable of performing the required exercise training
You will not qualify if you...
- Unstable coronary heart disease or heart failure
- Uncontrolled arrhythmias or severe aortic stenosis
- Acute myocarditis, endocarditis, or pericarditis
- Cancer requiring treatment in the past 5 years
- Autoimmune diseases affecting the immune system
- Plans to be away 4 weeks or more in the next year
- Pregnancy or anticipated pregnancy during the study
- Other life-threatening medical conditions or conditions that interfere with exercise
- Uncontrolled Diabetes (HbA1c ≥8.0)
- Hypertensive Blood Pressure ≥160 mm Hg Systolic and/or 100 mm Hg Diastolic
- Major risk factors for coronary heart disease (should consult a physician)
- Uncontrolled diabetes or musculoskeletal limitations (should consult a physician)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Physical Activity Research Center (PARC)
Pittsburgh, Pennsylvania, United States, 15219
Actively Recruiting
Research Team
D
Duck-chul Lee, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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