Actively Recruiting
Dosing of LT4 in Older Individuals
Led by University of Pennsylvania · Updated on 2026-02-19
228
Participants Needed
1
Research Sites
217 weeks
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Our overall goal is to determine the clinical consequences of allowing greater flexibility in LT4 dosing in older individuals who take LT4.
CONDITIONS
Official Title
Dosing of LT4 in Older Individuals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provide signed and dated informed consent
- Willingness to follow all study procedures and be available for the study duration
- Male or female aged 65 years or older, living in the community
- Diagnosed with hypothyroidism for at least 6 months and taking 75-200 mcg/day of LT4 with a minimum dose of 1.2 mcg/kg/day and no dose changes since last TSH test
- Able to take oral medication and willing to follow the medication regimen
- Adherence to lifestyle considerations
You will not qualify if you...
- Have hypopituitarism
- History of thyroid cancer requiring TSH suppression
- Currently using liothyronine (LT3), thyroid extracts, Tirosint liquid or capsules, or other medications affecting thyroid function
- Estimated glomerular filtration rate (GFR) less than 30 ml/min/1.73 m2 in past 12 months
- Unable to understand or follow study requirements as judged by study staff
- Any condition that would prevent full participation in the study
- Currently receiving multikinase or checkpoint inhibitor therapy
- History of food dye allergy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Penn Medicine, Smilow Translational Research Center
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
A
Anne R. Cappola, M.D., Sc.M.
CONTACT
T
Theresa M. Scattergood, M.S.N., R.N.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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