Update on the Management of Urological Problems Following Kidney Transplantation.
Mehmet Sarier, Ozlem Yayar, Asuman Yavuz...
https://pubmed.ncbi.nlm.nih.gov/33508852/Actively Recruiting
Led by Weill Medical College of Cornell University · Updated on 2026-05-22
438
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are studying urinary tract infections UTIs in kidney transplant recipients, a common and serious complication leading to illness and hospital visits. About 20% of newly transplanted patients develop UTIs within the first three months, which can increase the risk of bloodstream infection and kidney rejection. This study aims to evaluate whether a voiding technique called double voiding can reduce the incidence of UTIs in these patients. Participants will be randomly assigned to one of two groups one group will be taught to practice double voiding, which means passing urine twice each time to help empty the bladder more completely. The other group will continue with their usual voiding method. This intervention is being compared over the first three months after kidney transplantation to see if double voiding decreases UTI frequency. During the study, participants will be monitored for UTIs and related complications over three months post-transplant. Researchers will track the number and timing of UTIs, bacterial counts in urine cultures, bloodstream infections, and hospital admissions. These measures will help determine if double voiding offers benefits in reducing infections. The study is sponsored by Weill Medical College of Cornell University and started in April 2023, with completion expected by May 2027.
CONDITIONS
Double Voiding and Post-transplant UTI
M
Muthukumar Thangamani, M.D.
A
Ananda Kimm-Drapeau
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Weill Medical College of Cornell University
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Double Voiding (Scheduled Second Void) | Regular Voiding (Routine Care) |
|---|---|---|
| What is it? | Participants are asked to urinate twice in succession, emptying the bladder more thoroughly with an immediate second void after the first. | Participants continue their usual urination routine without instructions to double void. This reflects routine post-transplant practice. |
| Role in the trial | Acts as the experimental intervention intended to test whether a scheduled double void reduces UTI risk after kidney transplant. | Serves as the active comparator, representing established routine care for post-transplant recipients. |
| Primary use in clinical practice | Double voiding is proposed to help prevent urinary tract infections by improving bladder emptying; it is not standard in routine post-transplant care but is sometimes suggested for incomplete bladder emptying. | Regular voiding is the usual practice for kidney transplant patients in standard post-transplant follow-up. No scheduled intervention beyond routine urination is typically recommended for UTI prevention unless clinical risk factors are present. |
| How is it given or performed? | Participants are instructed to urinate, wait briefly, then try to urinate again immediately during each voiding episode. | Participants follow their customary urination pattern without added instructions or intervention. |
| Evidence status | Evidence for double voiding as a UTI prevention strategy in kidney transplant recipients is limited to ongoing clinical investigation; published studies do not establish its effectiveness for this purpose. Most evidence is indirect, focusing on theoretical reduction of residual urine. | Routine voiding is considered safe and consistent with current clinical practice. Published literature identifies regular voiding as standard care, with increased UTI risk associated with changes in bladder function or presence of a catheter rather than voiding strategy. |
| Important limitations | Double voiding may increase patient burden by requiring an extra urination effort. There is no published evidence supporting its efficacy for UTI reduction in kidney transplant recipients, and its impact on adherence or quality of life is not yet known. | Routine voiding may not address incomplete bladder emptying, which is a risk factor for UTI. Published evidence suggests UTI risk rises with other factors such as catheter use or structural abnormalities, but does not specifically implicate voiding practice. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - First 3 months after transplantation
Participants follow instructions to void either twice each time or normally to help reduce urinary tract infections after kidney transplantation.
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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Lead Sponsor