Actively Recruiting
Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma
Led by Bastiaan Driehuys · Updated on 2025-11-20
5
Participants Needed
1
Research Sites
93 weeks
Total Duration
On this page
Sponsors
B
Bastiaan Driehuys
Lead Sponsor
U
University of Kansas Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corresponding to the airways downstream of mucus plugs.
CONDITIONS
Official Title
Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to provide written informed consent
- Age between 18 and 65 years
- Diagnosed with asthma by a physician for more than 1 year
- Able to perform reproducible spirometry based on clinical pulmonary function tests within 30 days before enrollment
- All racial and ethnic backgrounds are eligible
- Blood eosinophil count greater than 300 cells/µL
- Smoking history less than 10 pack years
- No smoking (including vapes, cigars, or marijuana) within the last 3 months
- About to begin asthma treatment with dupilumab, tezepelumab, or benralizumab as part of standard care
You will not qualify if you...
- Respiratory tract infection within 4 weeks before first study visit
- Body mass index (BMI) over 30 at first study visit
- Received one-time doses such as intra-articular injections within 4 weeks before first visit
- Asthma-related emergency room visit within 4 weeks before first visit or during the study
- Significant other medical illnesses including heart disease, cancer, uncontrolled diabetes, or other chronic lung diseases
- Resting oxygen saturation below 90% even with maximum supplemental oxygen by nasal cannula
- Positive urine pregnancy test at first visit or anytime during the study
- Participation in another intervention study or use of investigational drugs within 30 days before enrollment or plans to enroll during the study
- Unable or unlikely to complete study assessments as judged by the investigator
- Study intervention poses undue risk as judged by the investigator
- Conditions preventing MRI scanning as determined by MRI safety screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Duke University Medical Center
Durham, North Carolina, United States, 27713
Actively Recruiting
Research Team
D
David Mummy, PhD
CONTACT
B
Bastiaan Driehuys, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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