Actively Recruiting
Doxycycline for Helicobacter Pylori Rescue Treatment
Led by Shanghai Jiao Tong University School of Medicine · Updated on 2024-12-30
368
Participants Needed
1
Research Sites
123 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Current guidelines have recommended classical bismuth-containing quadruple therapy including proton-pump inhibitor, bismuth, tetracycline, metronidazole as the empirical rescue therapy. However, tetracycline is clinically unavailable in China and the high frequency of adverse events of bismuth quadruple therapy often result in poor compliance, which limited the applicability of this recommendation. This study aimed to compare the efficacy and tolerability of a 14-day bismuth-containing quadruple rescue therapy in which tetracycline was replaced by doxycycline.
CONDITIONS
Official Title
Doxycycline for Helicobacter Pylori Rescue Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability and willingness to participate in the study and to sign and give informed consent
- Confirmed Helicobacter pylori infection with previous treatment failure
- Age between 18 and 70 years
You will not qualify if you...
- Never treated before for Helicobacter pylori infection
- Younger than 18 or older than 80 years
- History of stomach removal surgery (gastrectomy)
- Pregnant or breastfeeding women
- Severe systemic diseases or cancer
- Use of antibiotics, bismuth, antisecretory drugs, or Chinese herbal medicine within the last 8 weeks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Shanghai, Shanghai Municipality, China, 200127
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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