Comparing Doxycycline and Tetracycline Bismuth Quadruple Therapies for Helicobacter Pylori Rescue Treatment in Adults

What this Trial Is About

Researchers are comparing two types of 14-day bismuth-containing quadruple rescue therapies for people with Helicobacter pylori infection who have not been successfully treated before. The study focuses on replacing tetracycline with doxycycline to address tetracyclines unavailability in China and the high rate of side effects that reduce treatment adherence. This is a randomized controlled trial sponsored by Shanghai Jiao Tong University School of Medicine to assess effectiveness and tolerability. Participants receive either esomeprazole, bismuth potassium citrate, tetracycline, and metronidazole or esomeprazole, bismuth potassium citrate, doxycycline, and metronidazole. The treatments are given over 14 days with specific dosages and schedules esomeprazole twice daily, bismuth four times daily, metronidazole four times daily, and either tetracycline four times daily or doxycycline twice daily. This setup allows comparison of the two regimens as rescue therapies. During the trial, participants are monitored for treatment effectiveness by checking Helicobacter pylori eradication six weeks after therapy ends. Researchers also assess adverse effects and how well participants follow the treatment within seven days after finishing therapy. The total participation period includes treatment and follow-up visits to evaluate these outcomes and ensure safety.

Doxycycline for Helicobacter Pylori Rescue Treatment