Actively Recruiting
Doxycycline and Progestin Therapy for Chronic Endometritis(CE) in Patients With Recurrent Reproductive Failure(RRF)
Led by Fang Wang · Updated on 2026-03-23
1000
Participants Needed
1
Research Sites
403 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A Prospective Randomized Controlled Trial, the goal of this clinical trial is to evaluate the efficacy and safety of doxycycline alone versus doxycycline plus medroxyprogesterone acetate (MPA) in women with chronic endometritis (CE), and to assess subsequent reproductive outcomes. Participants will be randomly assigned to one of two groups and will receive the assigned treatment. Participants will be followed for reproductive outcomes, including pregnancy , ongoing pregnancy, spontaneous miscarriage, and live birth.
CONDITIONS
Official Title
Doxycycline and Progestin Therapy for Chronic Endometritis(CE) in Patients With Recurrent Reproductive Failure(RRF)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 20 to 45 years
- Plan to conceive within 12 months
- Chronic endometritis confirmed by endometrial CD138 immunohistochemistry
- Diagnosis of recurrent reproductive failure
- Willingness to undergo hysteroscopy and endometrial biopsy
- No contraindications to the study medications
You will not qualify if you...
- Acute genital tract infection, gynecologic malignancy, endometrial hyperplasia, or uterine fibroids
- Pregnancy or lactation
- Contraindications to hysteroscopy or anesthesia
- Use of antibiotics, glucocorticoids, estrogens, or progestins within 3 months before trial
- Allergy to doxycycline or medroxyprogesterone acetate
- Abnormal semen parameters in the male partner
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Lanzhou University Second Hospital
Lanzhou, Gansu, China, 730030
Actively Recruiting
Research Team
F
Fang Wang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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