Actively Recruiting
DPTX3186 in Wnt Pathway Activated Solid Tumors
Led by Dewpoint Therapeutics · Updated on 2026-01-12
40
Participants Needed
2
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a first-in human clinical study of DPTX3186 in subjects with Wnt-pathway activated solid tumors where no other treatments exist. The study will evaluate safety, pharmacokinetics, and initial activity of DPTX3186, as well as explore pharmacodynamic parameters to identify potential biomarkers of efficacy
CONDITIONS
Official Title
DPTX3186 in Wnt Pathway Activated Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically or cytologically confirmed solid tumor known to activate the Wnt pathway (e.g., colorectal cancer, gastric cancer, lung cancer, triple negative breast cancer) with no approved treatment options
- At least one measurable target lesion as defined by RECIST v1.1 on CT, PET/CT, or MRI
- ECOG performance status of 0 or 1
- Physiological conditions allowing oral medication absorption (no colostomy or ileostomy)
- Age 18 years or older (or age of majority per local regulation)
- Life expectancy of at least 3 months
- Willing and able to comply with study protocol requirements
You will not qualify if you...
- Symptomatic or uncontrolled brain metastasis requiring concurrent treatment
- Another malignancy progressing or requiring active treatment within last 2 years (except basal cell carcinoma, in situ cervical cancer, etc.)
- Inadequate organ function
- Known hypersensitivity to study drug or its ingredients
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
NEXT San Antonio
San Antonio, Texas, United States, 78229
Actively Recruiting
2
NEXT Virginia
Fairfax, Virginia, United States, 22031
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
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