Actively Recruiting
DREAM: Double Lung Transplant REgistry Aimed for Lung-limited Malignancies
Led by Northwestern University · Updated on 2024-11-14
125
Participants Needed
1
Research Sites
519 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective observational registration trial for patients who undergo lung transplantation for the treatment of the select groups of medically refractory cancers affecting the lungs alone without extrapulmonary nodal and distant metastasis.
CONDITIONS
Official Title
DREAM: Double Lung Transplant REgistry Aimed for Lung-limited Malignancies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 80 years
- Undergoing double lung transplantation as part of the clinical program
- Medically refractory lung cancers limited to the lungs without extrapulmonary disease
- Good general health with ability to withstand physical stress and psychosocial evaluation
- Meet all other lung transplant criteria including insurance approval and UNOS registration
- Histologically confirmed selected lung non-small cell lung cancers without distant or brain metastasis (Cohort A)
- Metastatic cancers confined to the lung only without other distant metastases (Cohort B)
- Respiratory failure with a history of cancer in the last 5 years without distant metastasis (Cohort C)
You will not qualify if you...
- Adults unable or unwilling to consent
- Individuals younger than 18 years (infants, children, teenagers)
- Pregnant women
- Prisoners
- Vulnerable populations
- Presence of extrapulmonary disease or mediastinal nodal disease at transplant referral
- Small cell lung cancers
- Unidentified primary cancer site in Cohort A
- Disease progression or distant metastases during transplant work-up
- Medical ineligibility for lung transplantation
- Not suitable for lung transplant per protocol for lung-confined tumors
- Body mass index over 35 kg/m2
- Co-existing malignancies in Cohort A
- Untreatable major organ dysfunction unless combined transplant planned
- Uncorrected atherosclerotic disease causing organ ischemia or coronary disease not treatable
- Uncorrectable bleeding disorders
- Active Mycobacterium tuberculosis infection
- Severe chest wall or spinal deformities expected to severely restrict lung function post-transplant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Thoracic Surgery, Canning Thoracic Institute (Northwestern Memorial Hospital)
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
L
Lung Transplant Thoracic Surgery, Canning Thoracic Institute (Northwestern Memorial Hospital)
CONTACT
L
Liam Il-Young Chung, MD MPH
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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