Prospective Observational Study of Double Lung Transplantation for Medically Refractory Lung-Limited Cancers DREAM Registry of Lung Transplant Outcomes in Patients Without Distant Metastasis

What this Trial Is About

Researchers are observing patients who receive double lung transplants to treat certain medically resistant cancers limited to the lungs without spread to other parts of the body. This study focuses on understanding outcomes after lung transplantation for selected lung cancers and metastases, including those with no other treatment options and good general health. The goal is to assess survival, disease recurrence, and graft function over time in carefully selected patients. Participants undergo double lung transplantation as part of their clinical care. The study includes three groups patients with primary lung cancers, patients with lung-only metastases from other cancers, and patients with respiratory failure plus recent cancer history. The study monitors patients after transplant to analyze survival and disease progression rates at multiple intervals, from 30 days up to 5 years. Throughout the study, patients will have ongoing assessments including survival status, disease-free status, and graft health at various time points. Researchers will also collect molecular and genetic data to explore links with patient outcomes. The study will continue monitoring participants long-term to better understand factors that affect post-transplant success in this unique patient population.

DREAM: Double Lung Transplant REgistry Aimed for Lung-limited Malignancies