Actively Recruiting
Drinking, Acetate, and Stress
Led by Yale University · Updated on 2025-07-28
50
Participants Needed
2
Research Sites
268 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
N
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to learn how drinking alcohol affects how people experience stress and how that is affected by the body's chemistry. Specifically, the investigators will be studying relationships of drinking and a stress hormone called cortisol. The investigators believe that results will lead us to find more effective ways to help people stop or reduce drinking when participants are drinking at harmful levels.
CONDITIONS
Official Title
Drinking, Acetate, and Stress
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form
- Willingness to comply with all study procedures and availability for the study duration
- Medically stable males or females aged 18 to 55
- Able to read, write, and complete self-assessments in English
- Meets DSM-5 criteria for current Alcohol Use Disorder
- Actively drinking participants with Alcohol Use Disorder must be willing to receive up to 30 days of inpatient treatment at no cost
- Participants sober for three months or longer are not required to undergo inpatient treatment
You will not qualify if you...
- Significant current medical conditions including neurological, cardiovascular, endocrine, thyroid, renal, liver disorders, seizures (except alcohol detox-related for LTS subjects), delirium, hallucinations, or unstable medical issues including HIV
- Current DSM-5 substance use disorder other than Alcohol Use Disorder or tobacco use disorder
- Presence of metallic implants making MRI unsafe (e.g., pacemaker)
- Claustrophobia or inability to undergo MRI
- Positive urine drug screen for illicit drugs at intake or follow-up visits
- Pregnant or nursing women, or those with an IUD unsafe for imaging
- Recent use of medications affecting study outcomes such as disulfiram, naltrexone, acamprosate, anticonvulsants
- Likely to have clinically significant alcohol withdrawal during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
The Anlyan Center, 300 Cedar St.
New Haven, Connecticut, United States, 06519
Actively Recruiting
2
Yale University
New Haven, Connecticut, United States, 06520
Not Yet Recruiting
Research Team
G
Graeme Mason, Ph.D.
CONTACT
E
Elizabeth Guidone, B.A.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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