What is Drospirenone studying for contraception in this trial?

The study is evaluating how Drospirenone affects cervical mucus changes in obese women before and after bariatric surgery. Researchers want to understand how the hormone-only pill influences cervical mucus, which is important for contraception. The trial is led by Chulalongkorn University and focuses on this specific population.

Who may be eligible for this contraception clinical trial?

Women aged 18 to 45 years who are obese and scheduled for bariatric surgery may be eligible. Participants must need contraception, be able to use non-hormonal birth control during the study, and provide consent. Please review eligibility criteria for more details.

Is there any cost to participate in this contraception clinical trial?

Study-related care, including the study drug and all trial visits, is provided at no cost. However, any personal travel expenses or other costs related to participation may vary and are not guaranteed to be covered.

Actively Recruiting

Phase Not Applicable

Age: 18Years - 45Years

FEMALE

ID06345586

Study of Drospirenone Pills on Cervical Mucus Changes Before and After Bariatric Surgery in Obese Thai Women Aged 18-45

Led by Chulalongkorn University · Updated on 2026-03-18

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

This research aims to study the effect of Drospirenone on cervical mucus changes in obese Thai women undergoing bariatric surgery. The study specifically evaluates cervical mucus using the modified Insler score before and after bariatric surgery to understand how the hormone-only pill impacts cervical mucus in this population. Participants will take a Drospirenone-only pill 4 mg once daily for 21 to 28 days. Cervical mucus will be assessed on days 4 to 7 of taking the medication. The study compares results from one month before bariatric surgery with results from one month after the surgery to observe any differences. Throughout the study, participants will provide cervical mucus samples for scoring, and hormone levels of estrogen and progesterone will be measured over time before and after surgery. Researchers will also monitor any treatment-related adverse events during the one-month period. The trial is expected to continue until July 2026, with all evaluations occurring close to the bariatric surgery timeline.

CONDITIONS

Brief Title

Drospirenone Only Pills and Cervical Mucus Changes: A Pre- and Post-Bariatric Surgery Study

Who Can Participate

Age: 18Years - 45Years

FEMALE

Eligibility Criteria

You may qualify if you...

Thai women aged 18 to 45 years who are obese and scheduled for bariatric surgery at Chulalongkorn Hospital
Need contraception
Able to use non-hormonal contraception during the study
Able and willing to give consent

You will not qualify if you...

Currently pregnant or have given birth within the past 3 months
Breastfeeding within the past 6 months
History of using DMPA within the past 12 months
History of using other hormonal birth control pills within the past 4 weeks
History of bilateral oophorectomy or hysterectomy
Suspected ovarian tumor or pathological ovarian cyst
Regular cigarette smoking
Any contraindications to Drospirenone

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - 21 to 28 days

Participants take Drospirenone 4 mg tablet orally once daily for 21 to 28 days. Cervical mucus is evaluated during this period.

1 baseline visit and 1 follow-up visit during treatment

Treatment

Duration - 21 to 28 days

Participants take Drospirenone 4 mg tablet orally once daily for 21 to 28 days after bariatric surgery. Cervical mucus is evaluated during this period.

1 baseline visit and 1 follow-up visit during treatment