Actively Recruiting
Drug-Drug Interaction Study of Atumelnant in Healthy Participants
Led by Crinetics Pharmaceuticals Inc. · Updated on 2026-05-06
46
Participants Needed
1
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to evaluate the impact of strong CYP3A4 induction on the pharmacokinetics (PK) of atumelnant, as well as the effect of atumelnant on CYP3A4, P-gp, and MATE1/2-K substrates in healthy participants.
CONDITIONS
Official Title
Drug-Drug Interaction Study of Atumelnant in Healthy Participants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy adult males or females of non-childbearing potential aged 19-55 years at screening
- Body mass index (BMI) between 18.0 and 32.0 kg/m2 at screening
- Willing and able to follow all study procedures, restrictions, fasting, standardized meals, inpatient admission, follow-up, and abstain from tobacco, alcohol, drugs, and strenuous exercise during the study
- Normal ACTH-stimulated cortisol test at screening without signs of adrenal insufficiency as judged by the investigator
You will not qualify if you...
- Mentally or legally incapacitated or with significant emotional problems at screening or expected during the study
- History or presence of clinically significant medical or psychiatric conditions as judged by the investigator
- Female participants with a positive pregnancy test at screening or first check-in or who are lactating
- Female participants of childbearing potential
- Previous treatment with atumelnant
- Participation in another clinical study within 30 days or receipt of any investigational drug within 5 half-lives before first dosing
- History or presence of hypersensitivity or idiosyncratic reaction to study drugs or related compounds
- Blood loss of 500 mL or more or blood donation within 3 months prior to first dosing
- Unable to avoid or expect to use any drugs, supplements, or herbal remedies within 14 days or 5 half-lives prior to first dosing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Crinetics Study Site
Lincoln, Nebraska, United States, 68502
Actively Recruiting
Research Team
C
Crinetics Clinical Trials
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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