Actively Recruiting
Drug-drug Interaction Study With AZD5335 and Itraconazole in Participants With Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Led by AstraZeneca · Updated on 2026-04-02
24
Participants Needed
9
Research Sites
89 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to assess the effect of itraconazole on the pharmacokinetics (PK) of AZ14170132.
CONDITIONS
Official Title
Drug-drug Interaction Study With AZD5335 and Itraconazole in Participants With Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female participants with platinum-resistant, relapsed, high-grade epithelial ovarian cancer, primary peritoneal cancer, or fallopian tube cancer
- Received at least 1 prior platinum-containing chemotherapy and progressed on or within 6 months after last dose
- Prior treatment with bevacizumab and/or PARP inhibitors according to local guidelines, unless ineligible
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
You will not qualify if you...
- Spinal cord compression or history of leptomeningeal carcinomatosis
- Unresolved toxicities of Grade 2 or higher from prior therapy
- History of non-infectious interstitial lung disease or pneumonitis requiring steroids or oxygen, or suspected ILD/pneumonitis not ruled out by imaging
- Uncontrolled intercurrent illness within 12 months before screening
- Any contraindication to itraconazole as per prescribing information and Investigator's judgment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
Research Site
Batumi, Georgia, 6010
Not Yet Recruiting
2
Research Site
Tbilisi, Georgia, 0114
Not Yet Recruiting
3
Research Site
Tbilisi, Georgia, 112
Not Yet Recruiting
4
Research Site
Dublin, Ireland, D07 R2WY
Actively Recruiting
5
Research Site
Lisbon, Portugal, 1250-068
Actively Recruiting
6
Research Site
Barcelona, Spain, 08023
Actively Recruiting
7
Research Site
Logroño, Spain, 26006
Actively Recruiting
8
Research Site
Madrid, Spain, 28040
Actively Recruiting
9
Research Site
Madrid, Spain, 28050
Actively Recruiting
Research Team
A
AstraZeneca Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here