Actively Recruiting

Phase 1
Age: 19Years - 55Years
MALE
Healthy Volunteers
NCT07548606

A Drug-Drug Interaction Study of Itraconazole and Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-017)

Led by Merck Sharp & Dohme LLC · Updated on 2026-04-30

14

Participants Needed

1

Research Sites

5 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers have designed a study medicine called opevesostat as a new way to treat prostate cancer. The purpose of this study is to learn what happens to opevesostat in a person's body over time (a pharmacokinetic or PK study). Researchers will compare what happens to opevesostat in the body when it is given with and without another medicine called itraconazole.

CONDITIONS

Official Title

A Drug-Drug Interaction Study of Itraconazole and Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-017)

Who Can Participate

Age: 19Years - 55Years
MALE
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Body mass index between 18.0 and 32.0 kg/m²
  • Medically healthy with no clinically significant medical history
  • Male gender
  • Age between 19 and 55 years
Not Eligible

You will not qualify if you...

  • History or presence of adrenal insufficiency
  • Hepatic or renal impairment
  • Clinically significant hypotension
  • Cardiac arrhythmia or conduction abnormalities
  • Recurrent unexplained syncopal events
  • Second- or third-degree atrioventricular heart block
  • Clinically significant sick sinus syndrome
  • Any systemic fungal infection
  • Chronic infection
  • Glaucoma
  • Hypothyroidism
  • Stomach ulcer
  • Ocular herpes simplex
  • Ventricular dysfunction or risk factors for Torsades de Pointes (e.g., heart failure, cardiomyopathy, family history of Long QT Syndrome)
  • History of cancer (malignancy)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

Celerion, Inc. ( Site 0001)

Lincoln, Nebraska, United States, 68502

Actively Recruiting

Loading map...

Research Team

T

Toll Free Number

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

SEQUENTIAL

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here

A Drug-Drug Interaction Study of Itraconazole and Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-017) | DecenTrialz