Actively Recruiting
Drug-Eluting Bead-Based Transarterial Chemoembolization (DEB-TACE) as a Local Salvage Therapy for Large Lesions in Relapsed and Refractory Diffuse Large B-Cell Lymphoma
Led by Ting YANG · Updated on 2025-11-18
10
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Current exploration of local therapies for large Diffuse Large B-Cell Lymphoma (DLBCL) masses remains in its infancy. This study aims to retrospectively evaluate the safety, efficacy, and tolerability of Drug-Eluting Bead-Based Transarterial Chemoembolization (DEB-TACE) for treating recurrent and refractory DLBCL masses. It seeks to establish a novel local salvage treatment strategy for such patients while providing preliminary theoretical foundations and clinical data to support future large-scale, multicenter clinical trials.
CONDITIONS
Official Title
Drug-Eluting Bead-Based Transarterial Chemoembolization (DEB-TACE) as a Local Salvage Therapy for Large Lesions in Relapsed and Refractory Diffuse Large B-Cell Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- Pathologically confirmed diffuse large B-cell lymphoma (DLBCL)
- Recurrence or resistance after multiple treatments including chemotherapy, immunotherapy, or targeted therapy
- Presence of at least one bulky lesion 5 cm or larger or confirmed by imaging
- Lesions have rich blood supply confirmed by CT, MRI, or PET-CT suitable for transarterial therapy
- Previous positive response to doxorubicin-based therapy
- ECOG performance status of 2 or less
- Blood counts, liver, kidney, and coagulation tests within specified safe limits
- At least one prior DEB-TACE treatment at this institution
You will not qualify if you...
- Severe heart, lung, liver, or kidney problems preventing safe treatment
- Active or uncontrolled serious infections
- Severe bleeding disorders or coagulation problems
- Pregnancy, breastfeeding, or planning pregnancy during the study
- Allergies or contraindications to drug-eluting beads or chemotherapy drugs
- Psychiatric or cognitive issues that prevent following treatment and follow-up
- Any other condition the investigator considers unsuitable for participation
AI-Screening
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Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China, 350001
Actively Recruiting
Research Team
X
Xiaoquan ji
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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